Home LiteratureArticle Details
PMID: 4998655 Published · ppublish English Journal Article

Biologicl activity and synthesis of an encephalitogenic determinant.

Science (New York, N.Y.) ·Vol. 173 ·No. 3998 ·1971-08-20 ·Pages 736-8

Shapira R, Chou FC, McKneally S, Urban E, Kibler RF

Abstract

A 45-residue fragment of the basic protein of myelin is encephalitogenic in the rabbit and monkey but relatively inactive in the guinea pig. Synthetic peptides containing the sequence of a tryptic peptide of the fragment Thr-Thr-His-Tyr-Gly-Ser-Leu-Pro-Gln-Lys are moderately encephalitogenic.

MeSH Terms
Amino Acid Sequence Animals Brain/pathology Central Nervous System/pathology Encephalitis/chemically induced,pathology Guinea Pigs Haplorhini Nerve Tissue Proteins/chemical synthesis Peptides/administration & dosage,chemical synthesis,toxicity Rabbits
Chemicals
Nerve Tissue Proteins Peptides
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Shapira R
Chou F C
McKneally S
Urban E
Kibler R F
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.173.3998.736
Published
1971-08-20
Pages
736-8
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.173.3998.736 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2