Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6-dimycolate (cord factor) and living bacillus Calmette Guérin.

Science (New York, N.Y.) ·Vol. 174 ·No. 4015 ·1971-12-17 ·Pages 1240-2

Bekierkunst A, Levij IS, Yarkoni E

Abstract

Trehalose-6,6-dimycolate (cord factor), a glycolipid from mycobacteria, suppressed the development of urethan-induced tumors in the lungs of mice to a similar degree as living Mycobacterium bovis (strain BCG) bacilli. The inhibition was apparently due to the host cellular reaction caused locally by cord factor.

MeSH Terms

Adenoma/chemically induced,drug therapy,pathology,therapy Animals BCG Vaccine/administration & dosage Glycolipids/isolation & purification,therapeutic use Granuloma/etiology Injections, Intraperitoneal Injections, Intravenous Lung/pathology Lung Neoplasms/chemically induced,drug therapy,pathology,therapy Mice Mycobacterium tuberculosis/analysis Neoplasms, Experimental/drug therapy Urethane

Chemicals

BCG Vaccine Glycolipids Urethane

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bekierkunst A

Levij I S

Yarkoni E

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.174.4015.1240

Published

1971-12-17

Pages

1240-2

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.174.4015.1240 View journal details

Analysis Services

Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6-dimycolate (cord factor) and living bacillus Calmette Guérin.

Contact

WeChat Official Account