Macrophage cytophilic antibody in mice: mechanism of action of bacterial lipopolysaccharide on the uptake of immunoglobulins by mouse peritoneal cells.

Infection and immunity ·Vol. 4 ·No. 4 ·1971-10-00 ·Pages 402-6

Tizard IR

Abstract

The action of injected bacterial lipopolysaccharide upon the uptake of cytophilic antibodies by macrophages was found to be unrelated either to changes in surface charge or to the rate of anaerobic glycolysis of these cells. It is apparently mediated by alterations in the levels of material in the serum which enhances the uptake of cytophilic antibody by macrophages. This enhancing material does not appear to be an immunoglobulin nor can it be generated by the action of endotoxin on either whole blood or serum.

MeSH Terms

Anaerobiosis Animals Antibodies, Bacterial Carbon Dioxide/biosynthesis Electrophoresis Endotoxins/pharmacology Erythrocytes/immunology Female Glycolysis Immunodiffusion Immunoglobulin G/analysis Immunoglobulins Kinetics Lipopolysaccharides Macrophages/immunology,metabolism Male Mice Peritoneum/immunology Polysaccharides, Bacterial Salmonella enteritidis Sheep/immunology Shigella dysenteriae

Chemicals

Antibodies, Bacterial Endotoxins Immunoglobulin G Immunoglobulins Lipopolysaccharides Polysaccharides, Bacterial Carbon Dioxide

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Tizard I R

References (13)

13 references, click to expand

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Macrophage cytophilic antibody in mice: effect of bacterial lipopolysaccharide on the uptake of immunoglobulins by mouse peritoneal cells.
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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.4.4.402-406.1971

Published

1971-10-00

Pages

402-6

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC416321

Subset

External Links

PubMed source DOI: 10.1128/iai.4.4.402-406.1971 PMC Full Text View journal details

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Macrophage cytophilic antibody in mice: mechanism of action of bacterial lipopolysaccharide on the uptake of immunoglobulins by mouse peritoneal cells.

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