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PMID: 5024722 Published · ppublish English Journal Article

Intestinal bacterial flora and bile salt studies in hypogammaglobulinaemia.

Gut ·Vol. 13 ·No. 3 ·1972-03-00 ·Pages 182-8

Parkin DM, McClelland DB, O'Moore RR, Percy-Robb IW, Grant IW, Shearman DJ

Abstract

Five patients with adult acquired hypogammaglobulinaemia, four of whom were achlorhydric, were studied. Jejunal bacterial counts were much higher than those in a control group of acid secretors, but were similar to those in a control group of patients with pernicious anaemia; Giardia lamblia were isolated from the jejunal content of all patients with hypogammaglobulinaemia. The concentration of conjugated bile acids in the fasting state was lower in hypogammaglobulinaemia than in pernicious anaemia, but in the two hypogammaglobulinaemic patients with steatorrhoea there was a normal bile salt response to a fatty meal.

MeSH Terms
Adult Agammaglobulinemia/microbiology,physiopathology Aged Anemia, Pernicious/microbiology Bile Acids and Salts/metabolism Biopsy Celiac Disease/complications Fats/analysis Feces/analysis Female Giardia/isolation & purification Humans Immunoglobulin A/metabolism Intestine, Small/microbiology Intestines/microbiology Jejunum/microbiology Male Middle Aged Vitamin B 12
Chemicals
Bile Acids and Salts Fats Immunoglobulin A Vitamin B 12
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Parkin D M
McClelland D B
O'Moore R R
Percy-Robb I W
Grant I W
Shearman D J
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26 references, click to expand
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.13.3.182
Published
1972-03-00
Pages
182-8
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1412127
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.13.3.182 PMC Full Text View journal details
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