Development of sensitivity to tetrodotoxin in beating chick embryo hearts, single cells, and aggregates.

Science (New York, N.Y.) ·Vol. 176 ·No. 4040 ·1972-06-16 ·Pages 1248-50

McDonald TF, Sachs HG, DeHaan RL

Abstract

The spontaneous activity of intact embryonic heart becomes progressively more sensitive to tetrodotoxin block with increasing age of the embryo. The activity of isolated single heart cells in culture was relatively insensitive, independent of embryo age. Aggregates formed from single cells responded to tetrodotoxin in the same manner as intact hearts; aggregated cells from older hearts were sensitive.

MeSH Terms

Animals Cell Aggregation Cells, Cultured Chick Embryo/drug effects Fetal Heart/drug effects Gestational Age Heart/physiology In Vitro Techniques Myocardium/cytology Tetrodotoxin/pharmacology

Chemicals

Tetrodotoxin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

McDonald T F

Sachs H G

DeHaan R L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.176.4040.1248

Published

1972-06-16

Pages

1248-50

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.176.4040.1248 View journal details

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Development of sensitivity to tetrodotoxin in beating chick embryo hearts, single cells, and aggregates.

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