Salicylate: a structure-activity study of its effects on membrane permeability.

Science (New York, N.Y.) ·Vol. 176 ·No. 4042 ·1972-06-30 ·Pages 1423-5

Levitan H, Barker JL

Abstract

Salicylate atnd benzoate, and their anlalogs, reversibly increase the membrane potetntial and conductance of identified molluscan neurons by increasing potassium conductance and decreasing chloride conductance. The relative potencies of these compounds were closely correlated with their octanol-water partition coefficients and their pK(a) values.

MeSH Terms

Animals Benzoates/pharmacology Cell Membrane Permeability/drug effects In Vitro Techniques Membrane Potentials/drug effects Mollusca Neurons/physiology Salicylates/pharmacology Structure-Activity Relationship

Chemicals

Benzoates Salicylates

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Levitan H

Barker J L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.176.4042.1423

Published

1972-06-30

Pages

1423-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.176.4042.1423 View journal details

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Salicylate: a structure-activity study of its effects on membrane permeability.

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