Inhibition of pancreatic secretion in man by cigarette smoking.

Gut ·Vol. 13 ·No. 5 ·1972-05-00 ·Pages 361-5

Bynum TE, Solomon TE, Johnson LR, Jacobson ED

Abstract

Cigarette smoking has been linked to an elevated incidence of duodenal ulcer disease in smokers, although the mechanism is unclear. In 23 young normal subjects single or double secretin tests were performed during non-smoking and smoking periods. Cigarette smoking inhibited the secretion of pancreatic juice and bicarbonate in light smokers (< one pack/day for < three years). Heavy smokers (> one pack/day for > three years) exhibited depressed pancreatic secretory rates during non-smoking periods. Inhibition of pancreatic alkaline secretion by cigarette smoking could be the link between the habit and duodenal ulcer disease.

MeSH Terms

Adult Bicarbonates/metabolism Duodenal Ulcer/etiology Humans Male Pancreas/metabolism Pancreatic Juice/metabolism Secretin Smoking/complications,physiopathology

Chemicals

Bicarbonates Secretin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bynum T E

Solomon T E

Johnson L R

Jacobson E D

References (16)

16 references, click to expand

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Article Info

Journal

Gut

Abbr.

Gut

ISSN

0017-5749

DOI

10.1136/gut.13.5.361

Published

1972-05-00

Pages

361-5

Language

English

Region

England

NLM ID

2985108R

PMCID

PMC1412225

Subset

External Links

PubMed source DOI: 10.1136/gut.13.5.361 PMC Full Text View journal details

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