The existence of DNA sequences homologous to adenovirus 5 DNA in the genome of normal rat cells.

Nucleic acids research ·Vol. 7 ·No. 6 ·1979-11-24 ·Pages 1419-28

Frolova EI, Georgiev GP

Abstract

Three discrete bands specifically hybridizing to adenovirus 5 DNA were found in the rat liver DNA restricted BY Bam HI endonuclease and fractionated electrophoretically. The hybridization with different regions of the viral genome takes place. Similar bands are present in the DNA from different lines of adenovirus 5 transformed cells, but in these cases high molecular weight DNA fragments containing the integrated viral genomes can also be found.

MeSH Terms

Adenoviridae/analysis Animals Base Sequence Cell Line Cell Transformation, Viral DNA DNA Restriction Enzymes DNA, Viral Embryo, Mammalian Nucleic Acid Hybridization Rats Species Specificity

Chemicals

DNA, Viral DNA DNA Restriction Enzymes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Frolova E I

Georgiev G P

References (15)

15 references, click to expand

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Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

0305-1048

DOI

10.1093/nar/7.6.1419

Published

1979-11-24

Pages

1419-28

Language

English

Region

England

NLM ID

0411011

PMCID

PMC342317

Subset

External Links

PubMed source DOI: 10.1093/nar/7.6.1419 PMC Full Text View journal details

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The existence of DNA sequences homologous to adenovirus 5 DNA in the genome of normal rat cells.

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