Intracellular calcium movements in skinned muscle fibres.
1. Force development and (45)Ca movement between the internal membranes and the myofilament space were measured in segments of skinned muscle fibres.2. At 20 degrees C calcium ions in the myofilament space of calcium loaded fibres caused the internal membranes to release a substantial amount of calcium which produced a large force spike. Calcium produced a similar force spike in fibres containing only the physiological level of calcium when the temperature was lowered to about 6 degrees C.3. The force spike at 6 degrees C was inhibited when the magnesium concentration in the bathing solution was increased from 1 to 6 mM. The pattern of force development in preparations transferred directly from oil to a free calcium solution indicated that the normal concentration of Mg(2+) in the myofilament space of intact fibres is of the order of 10(-3)M.4. A possible role for the regenerative calcium release mechanism in the physiological activation of muscle fibres is suggested.
19 references, click to expand
-
Local activation of striated muscle fibres.J Physiol. 1958 Dec 30;144(3):426-41 PMID: 13621406
-
Regenerative calcium release within muscle cells.Science. 1970 Jan 2;167(3914):58-9 PMID: 5409477
-
Effects of ATP on the interaction of Ca++, Mg++, and K+ with fragmented sarcoplasmic reticulum isolated from rabbit skeletal muscle.J Gen Physiol. 1967 May;50(5):1327-52 PMID: 6033589
-
The chemical energetics of muscle contraction. II. The chemistry, efficiency and power of maximally working sartorius muscles. Appendix. Free energy and enthalpy of atp hydrolysis in the sarcoplasm.Proc R Soc Lond B Biol Sci. 1969 Dec 23;174(1036):315-53 PMID: 4391323
-
REGULATION BY CALCIUM OF THE CONTRACTION AND RELAXATION OF MUSCLE FIBERS.Fed Proc. 1964 Sep-Oct;23:933-9 PMID: 14209825
-
Ionic mobility in muscle cells.Science. 1969 Dec 5;166(3910):1297-8 PMID: 5350329
-
The binding of calcium to actomyosin systems in relation to their biological activity.J Biol Chem. 1963 Feb;238:599-605 PMID: 13999360
-
Depolarization of the internal membrane system in the activation of frog skeletal muscle.J Gen Physiol. 1967 May;50(5):1101-24 PMID: 6033576
-
Ca fluxes in single twitch muscle fibers.J Gen Physiol. 1966 Nov;50(2):255-67 PMID: 11526827
-
Intracellular calcium movements of frog skeletal muscle during recovery from tetanus.J Gen Physiol. 1968 Jan;51(1):65-83 PMID: 4868186
-
LOCALIZATION OF CALCIUM-ACCUMULATING STRUCTURES IN STRIATED MUSCLE FIBERS.Science. 1965 Jan 8;147(3654):158-60 PMID: 14220445
-
Calcium uptake and force development by skinned muscle fibres in EGTA buffered solutions.J Physiol. 1972 May;223(1):1-19 PMID: 5046147
-
Excitation-contraction coupling in muscular response.Yale J Biol Med. 1952 Dec;25(3):176-201 PMID: 13015950
-
Myosin and adenosinetriphosphatase.Biochem J. 1942 Feb;36(1-2):121-39 PMID: 16747475
-
Calcium ion and muscle contraction.Prog Biophys Mol Biol. 1968;18:123-83 PMID: 4894870
-
The kinetics of mechanical activation in frog muscle.J Physiol. 1969 Sep;204(1):207-30 PMID: 5352046
-
Calcium efflux from frog twitch muscle fibers.J Gen Physiol. 1970 Feb;55(2):243-53 PMID: 4984334
-
Calcium induced release of calcium from the sarcoplasmic reticulum of skinned skeletal muscle fibres.Nature. 1970 Oct 3;228(5266):34-6 PMID: 5456208
-
ADENOSINE TRIPHOSPHATE-LINKED CONCENTRATION OF CALCIUM IONS IN A PARTICULATE FRACTION OF RABBIT MUSCLE.J Cell Biol. 1962 Sep 1;14(3):389-400 PMID: 19866605
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