Axonal transport of gangliosides in the goldfish optic nerve.

Science (New York, N.Y.) ·Vol. 177 ·No. 4049 ·1972-08-18 ·Pages 630-3

Forman DS, Ledeen RW

Abstract

Radioactive glucosamine and N-acetylmannosamine injected into the goldfish eye are incorporated into gangliosides that undergo rapid axonal transport to the optic nerve terminals. All ganglioside fractions are labeled. These data provide the first evidence that axonal transport has a role in neuronal ganglioside function and metabolism.

MeSH Terms

Animals Axons/metabolism Biological Transport Carbon Isotopes Chromatography, Thin Layer Cyprinidae Gangliosides/biosynthesis,isolation & purification,metabolism Glucosamine/metabolism Hexosamines/metabolism Mannose/metabolism Optic Nerve/analysis,metabolism Retina/metabolism Tritium

Chemicals

Carbon Isotopes Gangliosides Hexosamines Tritium Glucosamine Mannose

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Forman D S

Ledeen R W

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.177.4049.630

Published

1972-08-18

Pages

630-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.177.4049.630 View journal details

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Axonal transport of gangliosides in the goldfish optic nerve.

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