Home LiteratureArticle Details
PMID: 50738 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cytidine deaminase: a new genetic polymorphism demonstrated in human granulocytes.

American journal of human genetics ·Vol. 27 ·No. 4 ·1975-07-00 ·Pages 492-7

Teng YS, Anderson JE, Giblett ER

Abstract

Cytidine deaminase in human white blood cells has three electrophoretic phenotypes representing the homozygous and heterozygous expression of two common alleles, CDA1 and CDA2, at an autosomal locus. To explain the multibanded pattern of the heterozygote, the enzyme is assumed to have a tetrameric structure.

MeSH Terms
Azacitidine Cytarabine Cytidine/analogs & derivatives Cytidine Deaminase/analysis Cytosine Electrophoresis, Starch Gel Female Granulocytes/enzymology Humans Leukocytes/enzymology Male Nucleoside Deaminases/analysis Pedigree Phenotype Polymorphism, Genetic
Chemicals
Cytarabine Cytidine Cytosine Nucleoside Deaminases Cytidine Deaminase Azacitidine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Teng Y S
Anderson J E
Giblett E R
References (12)
12 references, click to expand
  1. Deamination of 5-azacytidine by a human leukemia cell cytidine deaminase.
    Biochem Pharmacol. 1973 Nov 1;22(21):2763-5 PMID: 4128550
  2. Mechanisms of resistance of human acute leukaemia cells to cytosine arabinoside.
    Br J Haematol. 1974 May;27(1):39-46 PMID: 4368900
  3. Cytidine deaminase in human lymphocytes.
    Nat New Biol. 1973 Aug 15;244(137):217-9 PMID: 4516595
  4. Purification and properties of cytidine deaminase from normal and leukemic granulocytes.
    J Clin Invest. 1974 Mar;53(3):922-31 PMID: 4521417
  5. Studies of the enzymatic deamination of cytosine arabinoside. I. Enzyme distribution and species specificity.
    Biochem Pharmacol. 1965 Oct;14(10):1405-16 PMID: 4956026
  6. Cytidine deaminase and the development of resistance to arabinosyl cytosine.
    Nat New Biol. 1971 Sep 22;233(38):109-10 PMID: 5285962
  7. Nucleoside deaminase: an enzymatic marker for stress erythropoiesis in the mouse.
    J Clin Invest. 1970 Nov;49(11):2051-67 PMID: 5475986
  8. Effects of murine viral leukemia on spleen nucleoside deaminase: purification and properties of the enzyme from leukemic spleen.
    Biochim Biophys Acta. 1971 May 27;238(3):377-87 PMID: 5565891
  9. Mouse kidney cytidine deaminase. Purification and properties.
    J Biol Chem. 1968 May 25;243(10):2534-7 PMID: 5651639
  10. The purification and properties of cytidine aminohydrolase from sheep liver.
    Eur J Biochem. 1969 Jan;7(2):223-30 PMID: 5765735
  11. Regulatory mechanisms in the human leukocyte. I. The feedback control of deoxycytidylate deaminase.
    Blood. 1967 Jun;29(6):896-905 PMID: 6029004
  12. Lactate Dehydrogenase Isozymes: Dissociation and Recombination of Subunits.
    Science. 1963 Jun 21;140(3573):1329-30 PMID: 17802174
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1975-07-00
Pages
492-7
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1762802
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2