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PMID: 5076806 Published · ppublish English Journal Article

Resistance of Staphylococcus aureus to sulphamethoxazole and trimethoprim.

Journal of clinical pathology ·Vol. 25 ·No. 8 ·1972-08-00 ·Pages 708-12

Nakhla LS

Abstract

Strains of Staphylococcus aureus isolated from the lesions of hospital patients were surveyed for resistance to sulphamethoxazole and to trimethoprim. Of 675 strains tested, 18.5% were resistant to sulphamethoxazole and 1.6% to trimethoprim. All the trimethoprim-resistant strains were resistant to sulphamethoxazole and to a 1:20 mixture of the two drugs. Trimethoprim-resistant strains were on average more resistant to sulphamethoxazole than were trimethoprim-sensitive strains. They were all resistant to several other antimicrobial agents. Most of them had the phage-typing pattern 84/85, 84, or 85.

MeSH Terms
Anti-Bacterial Agents/pharmacology Bacitracin/pharmacology Bacteriophage Typing Drug Resistance, Microbial Folic Acid Antagonists/pharmacology Fusidic Acid/pharmacology Humans Lincomycin/pharmacology Microbial Sensitivity Tests Neomycin/pharmacology Oleandomycin Penicillin Resistance Pyrimidines/pharmacology Staphylococcus/drug effects Streptomycin/pharmacology Sulfamethoxazole/pharmacology Sulfonamides/pharmacology Tetracycline/pharmacology Trimethoprim/pharmacology
Chemicals
Anti-Bacterial Agents Folic Acid Antagonists Pyrimidines Sulfonamides Bacitracin Fusidic Acid Trimethoprim Lincomycin Tetracycline Neomycin Sulfamethoxazole Oleandomycin Streptomycin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Nakhla L S
References (11)
11 references, click to expand
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Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
0021-9746
DOI
10.1136/jcp.25.8.708
Published
1972-08-00
Pages
708-12
Language
English
Region
England
NLM ID
0376601
PMCID
PMC477483
Subset
IM
External Links
PubMed source DOI: 10.1136/jcp.25.8.708 PMC Full Text View journal details
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