Persistent binding of a new reaction product of the carcinogen N-hydroxy-N-2-acetylaminofluorene with guanine in rat liver DNA in vivo.

Acetamides/administration & dosage,metabolism Amines/metabolism Animals Carbon Isotopes Carcinogens/administration & dosage,metabolism Chromatography DNA/analysis,metabolism Fluorenes/administration & dosage,metabolism Guanine/metabolism Half-Life Hydrochloric Acid/pharmacology Hydroxylamines/administration & dosage,metabolism Liver/metabolism Male Nucleosides/analysis Protein Binding RNA/metabolism Rats Rats, Inbred Strains Sodium Hydroxide/pharmacology Time Factors Tritium

Acetamides Amines Carbon Isotopes Carcinogens Fluorenes Hydroxylamines Nucleosides Tritium Sodium Hydroxide Guanine RNA DNA Hydrochloric Acid