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PMID: 5091158 Published · ppublish English Journal Article

Antinociceptive activity of morphine after injection of biogenic amines in the cerebral ventricles of the conscious rat.

British journal of pharmacology ·Vol. 42 ·No. 2 ·1971-06-00 ·Pages 230-41

Sparkes CG, Spencer PS

Abstract

1. A simple cannula and a cannula guide for making injections into the cerebral ventricles of conscious rats are described.2. Intraventricular injections of 5-hydroxytryptamine (5-HT) or of noradrenaline (NA) were without effect on the nociceptive threshold of rats.3. Intraventricular injection of 5-HT potentiated the antinociceptive effect of morphine. Reserpine pretreatment antagonized the antinociceptive effect of morphine; this effect was reversed by intraventricular injection of 5-HT.4. Intraventricular injection of NA attenuated the antinociceptive action of morphine but was without effect on the inhibition by reserpine of the antinociceptive effect of morphine.5. Subcutaneous injection or slow intravenous infusion of either 5-HT or NA (up to 300 mug/rat) were without significant effect on the antinociceptive effects of morphine.6. Intraperitoneal administration of dopa increased the nociceptive threshold above normal, but reduced the antinociceptive effect of morphine. Intraventricular injection of either dopa or dopamine had no antinociceptive effect but inhibited that of morphine.7. It is suggested that the antinociceptive effect of morphine may depend on the balance between the concentrations of 5-HT and NA in the brain.

MeSH Terms
Animals Cerebral Ventricles/drug effects Consciousness Dihydroxyphenylalanine/administration & dosage,pharmacology Dopamine/pharmacology Injections Injections, Subcutaneous Male Morphine/antagonists & inhibitors,pharmacology Norepinephrine/administration & dosage,pharmacology Pain Postural Balance Rats Reserpine/pharmacology Serotonin/administration & dosage,pharmacology
Chemicals
Serotonin Dihydroxyphenylalanine Morphine Reserpine Dopamine Norepinephrine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sparkes C G
Spencer P S
References (27)
27 references, click to expand
  1. Neostigmine and opiate analgesia.
    Arch Int Pharmacodyn Ther. 1950 Jun 1;83(1):143-8 PMID: 15426376
  2. [Influenceability of the analgetic effect of morphine by reserpine].
    Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1958;235(1):1-9 PMID: 13613363
  3. Effect of 5-hydroxytryptamine on morphine analgesia in rabbits.
    Ann Med Exp Biol Fenn. 1969;47(2):113-23 PMID: 5360652
  4. SYMPATHOMIMETICS AS ANALGESICS: EFFECTS OF METHOXAMINE, METHAMPHETAMINE, METARAMINOL AND NOREPINEPHRINE.
    Life Sci. 1964 Apr;3:315-22 PMID: 14172945
  5. Effect of adrenaline on the analgesic response of mice to morphine and related drugs.
    Arch Int Pharmacodyn Ther. 1955 Nov 1;104(1):50-6 PMID: 13283643
  6. The influence of serotonine and amphetamine on analgesic effect of morphine after reserpine premedication in rats and mice.
    Med Pharmacol Exp Int J Exp Med. 1965;13(1):43-8 PMID: 5898621
  7. Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor.
    Psychopharmacologia. 1968;12(4):278-85 PMID: 5652213
  8. The effect of reserpine and alpha-methyldopa on the analgesic action of morphine in the mouse.
    J Pharm Pharmacol. 1967 Nov;19(11):709-13 PMID: 4383691
  9. Narcotic-antagonist analgesics: interactions with cholinergic systems.
    J Pharmacol Exp Ther. 1969 Sep;169(1):17-22 PMID: 4389919
  10. THE ACTION OF RESERPINE AND ALPHA-METHYL-M-TYROSINE ON THE ANALGESIC EFFECT OF MORPHINE IN RATS AND MICE.
    J Pharm Pharmacol. 1964 Mar;16:198-206 PMID: 14163982
  11. The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs.
    J Physiol. 1954 Mar 29;123(3):451-81 PMID: 13152692
  12. A method for measurement of analgesic activity on inflamed tissue.
    Arch Int Pharmacodyn Ther. 1957 Sep 1;111(4):409-19 PMID: 13471093
  13. Antagonism of analgesics by amine-depleting agents.
    J Pharm Pharmacol. 1965 May;17(5):326-7 PMID: 4378678
  14. Analgesic activity of some sympathetic drugs and their effect on morphine analgesia in rabbits.
    Ann Med Exp Biol Fenn. 1969;47(3):180-90 PMID: 4391627
  15. The effects of catecholamines on the central nervous system.
    Pharmacol Rev. 1959 Jun;11(2, Part 2):494-547 PMID: 13667432
  16. Synergism of amines and antagonism of reserpine to morphine analgesia.
    Proc Soc Exp Biol Med. 1958 Jan;97(1):97-100 PMID: 13518189
  17. ANTAGONISM OF THE ANALGETIC EFFECT OF MORPHINE IN MICE BY TETRABENAZINE AND RESERPINE.
    Arch Int Pharmacodyn Ther. 1964 Jun 1;149:484-92 PMID: 14191081
  18. Effect of reserpine and alpha-methyl-tyrosine on morphine analgesia.
    Int J Neuropharmacol. 1968 May;7(3):283-92 PMID: 5720518
  19. Reserpine antagonism of morphine analgesia in mice.
    Proc Soc Exp Biol Med. 1954 Dec;87(3):614-5 PMID: 13237323
  20. Potentiation of morphine analgesia by cocaine in mice.
    Eur J Pharmacol. 1968 Dec;5(1):93-9 PMID: 5718523
  21. Effect of reserpine and other drugs on the monoamine metabolism with special reference to the CNS.
    Ann Med Exp Biol Fenn. 1968;46(3):361-6 PMID: 4308996
  22. Acute tolerance to narcotic analgesic drugs in rats.
    Br J Pharmacol Chemother. 1968 Jun;33(2):245-56 PMID: 5664145
  23. STUDIES ON THE SITE OF ANALGESIC ACTION OF MORPHINE BY INTRACEREBRAL MICRO-INJECTION.
    Sci Sin. 1964 Jul;13:1099-109 PMID: 14196479
  24. [Differential influencing of analgesic and central stimulant effects of morphine by central depressant drugs].
    Helv Physiol Pharmacol Acta. 1957;15(1):105-15 PMID: 13428204
  25. Construction and implantation of a permanent cannula for making injections into the lateral ventricle of the rat brain.
    Life Sci. 1966 Aug;5(16):1509-15 PMID: 5969207
  26. Action of noradrenaline and reserpine on experimental analgesia.
    Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1957;232(1):279-81 PMID: 13526855
  27. Effects of drugs acting in relation to sympathetic functions on the analgesic action of morphine.
    Arch Int Pharmacodyn Ther. 1966 Apr;160(2):312-20 PMID: 4380922
Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1971.tb07104.x
Published
1971-06-00
Pages
230-41
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1667154
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1971.tb07104.x PMC Full Text View journal details
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