Linkage of genes controlling the rate of synthesis and structure of aminolevulinate dehydratase.

Science (New York, N.Y.) ·Vol. 173 ·No. 4003 ·1971-09-24 ·Pages 1245-6

Coleman DL

Abstract

The rate of synthesis of delta-aminolevulinate dehydratase in mice is controlled by alleles at the levulinate (Lv) locus. Two structural mutations modifying the sensitivity of delta-aminolevulinate dehydratase to heat have been identified. Genetic analyses established that the structural locus for delta-aminolevulinate dehydratase was either physically close to or identical with the locus that controls its rate of synthesis.

MeSH Terms

Alleles Animals Breeding Genes Genetic Linkage Genotype Hot Temperature Hybridization, Genetic Hydro-Lyases/analysis,biosynthesis Levulinic Acids Liver/enzymology Mice Mice, Inbred Strains Mutation Protein Denaturation

Chemicals

Levulinic Acids Hydro-Lyases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Coleman D L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.173.4003.1245

Published

1971-09-24

Pages

1245-6

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.173.4003.1245 View journal details

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Linkage of genes controlling the rate of synthesis and structure of aminolevulinate dehydratase.

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