Intestinal secretion: stimulation by peptides.

Science (New York, N.Y.) ·Vol. 174 ·No. 4007 ·1971-10-22 ·Pages 422-4

Barbezat GO, Grossman MI

Abstract

Two peptides isolated from intestinal mucosa, vasoactive intestinal peptide, and gastric inhibitory peptide, stimulate small intestinal secretion in conscious dogs. Glucagon and pentagastrin also stimulate, but secretin and the octapetide of cholecystokinin do not. The stimulants may participate in regulation of intestinal secretion in health and in diseases with excessive secretion.

MeSH Terms

Animals Bicarbonates/analysis Chlorides/analysis Cholecystokinin/pharmacology Dogs Gastrins/pharmacology Glucagon/pharmacology Ileum/drug effects Infusions, Parenteral Intestinal Mucosa/analysis,drug effects Intestinal Secretions/analysis,drug effects Jejunum/drug effects Peptides/administration & dosage,isolation & purification,pharmacology Potassium/analysis Secretin/pharmacology Sodium/analysis Stimulation, Chemical

Chemicals

Bicarbonates Chlorides Gastrins Peptides Secretin Glucagon Cholecystokinin Sodium Potassium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Barbezat G O

Grossman M I

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.174.4007.422

Published

1971-10-22

Pages

422-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.174.4007.422 View journal details

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