Development of adenylate kinase isoenzymes in rat liver.
Total adenylate kinase activity was determined in developing rat liver. The activity was 18 units/g wet weight of tissue in foetal liver; this increased to 41 units/g immediately after birth and continued increasing until adult activities of 150 units/g were reached after two weeks. The adenylate kinase activity was separated into four isoenzymes. Only isoenzymes II and III were observed in foetal rat liver. Isoenzyme II activity was 2 units/g in the foetal liver and increased to 25 units/g in adult liver. Adenylate kinase III activity was 20 units/g in the foetal liver and increased to 118 units/g in adult liver. The possible role that adenylate kinase might have in regulating the energy flow in the developing liver cell is discussed.
19 references, click to expand
-
Adenosine triphosphate-adenosine 5'-monophosphate phosphotransferase of bovine liver mitochondria. II. General kinetic and structural properties.J Biol Chem. 1966 Sep 25;241(18):4136-45 PMID: 5924638
-
Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver.Biochem J. 1967 Sep;104(3):866-71 PMID: 6049928
-
The effects of starvation and alloxan-diabetes on the contents of citrate and other metabolic intermediates in rat liver.Biochem J. 1968 Apr;107(3):411-5 PMID: 5650365
-
Metabolic regulation and enzyme alterations in the Morris hepatomas.Cancer Res. 1968 Sep;28(9):1897-900 PMID: 4300224
-
The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers.Biochemistry. 1968 Nov;7(11):4030-4 PMID: 4972613
-
Interaction between energy charge and product feedback in the regulation of biosynthetic enzymes. Aspartokinase, phosphoribosyladenosine triphosphate synthetase, and phosphoribosyl pyrophosphate synthetase.Biochemistry. 1968 Nov;7(11):4035-40 PMID: 4881060
-
Interaction between energy charge and metabolite modulation in the regulation of enzymes of amphibolic sequences. Phosphofructokinase and pyruvate dehydrogenase.Biochemistry. 1968 Nov;7(11):4041-5 PMID: 4301881
-
The heterogeneity of DNA polymerases in rat liver and hepatomas.Cancer Res. 1968 Dec;28(12):2466-76 PMID: 4302531
-
Enzymic differentiation in mammalian liver injection of fetal rats with hormones causes the premature formation of liver enzymes.Science. 1969 Feb 28;163(3870):891-5 PMID: 4387727
-
A new pyruvate kinase isozyme in hepatomas.Biochem Biophys Res Commun. 1969 Jun 27;35(6):901-5 PMID: 4307211
-
Separation of DNA polymerase from rat liver and hepatomas.Cancer Res. 1969 Aug;29(8):1562-7 PMID: 4308956
-
Induction of hepatic enzyme synthesis in vivo by adenosine 3', 5'-monophosphate.J Biol Chem. 1969 Nov 10;244(21):6008-13 PMID: 4390807
-
Adenine nucleotides and the adenylate kinase equilibrium in livers of foetal and newborn rats.Biochem J. 1970 Apr;117(2):231-5 PMID: 5420030
-
Premature formation of glucokinase in developing rat liver.J Biol Chem. 1970 Jun 10;245(11):2779-83 PMID: 4192987
-
Adenosine triphosphate: adenosine monophosphate phosphotransferase isozymes in rat liver and hepatomas.Cancer Res. 1970 Feb;30(2):370-5 PMID: 4394072
-
Rat liver adenosine triphosphate: adenosine monophosphate phosphotransferase activity. I. Purification and physical and kinetic characterization of adenylate kinase 3.J Biol Chem. 1970 Dec 10;245(23):6346-51 PMID: 5484813
-
Rat liver adenosine triphosphate: adenosine monophosphate phosphotransferase activity. II. Subcellular localization of adenylate kinase isozymes.J Biol Chem. 1970 Dec 10;245(23):6352-6 PMID: 5484814
-
Protein measurement with the Folin phenol reagent.J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
-
Glycogen metabolism in embryonic chick and neonatal rat liver.Biochim Biophys Acta. 1963 Jun 4;71:578-88 PMID: 13966157
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
