Inhibition of the amidase and kininogenase activities of pancreatic kallikrein by aromatic diamidines and an evaluation of diamidines for their in vivo use.

Amidines/pharmacology Amidohydrolases/antagonists & inhibitors Anilides Animals Blood Coagulation Tests Blood Pressure/drug effects Dogs Drug Antagonism Female Heparin Antagonists Hydrolysis Hypotension/chemically induced Kallikreins/antagonists & inhibitors Pancreas/enzymology Phenanthridines/pharmacology Structure-Activity Relationship Swine Thromboplastin Tolonium Chloride

Amidines Anilides Heparin Antagonists Phenanthridines Tolonium Chloride Thromboplastin Kallikreins Amidohydrolases