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PMID: 513081 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Alpha-thalassaemia in Cyprus.

Journal of medical genetics ·Vol. 16 ·No. 5 ·1979-10-00 ·Pages 363-5

Hadjiminas M, Zachariadis Z, Stamatoyannopoulos G

Abstract

The frequency of alpha-thalassaemia in Cyprus was determined with studies of haemoglobin Bart's in 1200 Greek Cypriot and 132 Turkish Cypriot newborn babies. Of the Greek newborns, 12.4%, and of the Turkish newborns, 6.8% had raised Hb Bart's (from 0.6% to 12.9% of the total haemoglobin) suggesting that they were carriers of either alpha-thalassaemia-1 or alpha-thalassaemia-2 genes. The findings suggest that the population of Cyprus has the highest frequencies of alpha-thalassaemia among Caucasian people.

MeSH Terms
Child, Preschool Cyprus Gene Frequency Greece/ethnology Hemoglobins, Abnormal/genetics Heterozygote Humans Infant, Newborn Thalassemia/genetics Turkey/ethnology
Chemicals
Hemoglobins, Abnormal
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hadjiminas M
Zachariadis Z
Stamatoyannopoulos G
References (7)
7 references, click to expand
  1. CASE OF INTRAUTERINE DEATH DUE TO ALPHA-THALASSAEMIA.
    Br Med J. 1965 Jul 31;2(5456):278-9 PMID: 14310209
  2. Identification of a nondeletion defect in alpha-thalassemia.
    N Engl J Med. 1977 Nov 17;297(20):1081-4 PMID: 909565
  3. Hemoglobin Bart's levels in umbilical cord blood: failure as a method for distinguishing mild from severe alpha-thalassemia trait in the Chinese.
    Hemoglobin. 1978;2(4):389-92 PMID: 701093
  4. The genetical interpretation of haemoglobin H disease.
    Hum Hered. 1970;20(2):156-64 PMID: 5489873
  5. The severe form of alpha thalassaemia is caused by a haemoglobin gene deletion.
    Nature. 1974 Oct 4;251(5474):389-92 PMID: 4138824
  6. Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis).
    Nature. 1974 Oct 4;251(5474):392-3 PMID: 4424635
  7. Alpha-thalassemia in Northern Thailand.
    Am J Hum Genet. 1970 Nov;22(6):645-51 PMID: 5518459
Article Info
Journal
Journal of medical genetics
Abbr.
J Med Genet
ISSN
0022-2593
DOI
10.1136/jmg.16.5.363
Published
1979-10-00
Pages
363-5
Language
English
Region
England
NLM ID
2985087R
PMCID
PMC1012610
Subset
IM
External Links
PubMed source DOI: 10.1136/jmg.16.5.363 PMC Full Text View journal details
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