Integration of viral genomes.

Nature ·Vol. 256 ·No. 5517 ·1975-08-07 ·Pages 471-3

Zhdanov VM

Abstract

DNA transcripts of infectious RNA viruses were found to be integrated in the DNA of chronically-infected tissue cultures. DNA sequences homologous to RNA of measles virus were found in tissues affected with systemic lupus erythemotosus. These data open up a new class of virus-cell interaction that may be a result of cooperation between infectious and oncogenic viruses.

MeSH Terms

Animals Chick Embryo Culture Techniques DNA, Viral/metabolism Dactinomycin/pharmacology Humans Lupus Erythematosus, Systemic/immunology,microbiology Measles virus/immunology,metabolism Oncogenic Viruses/metabolism RNA Viruses/metabolism RNA-Directed DNA Polymerase/metabolism Transcription, Genetic/drug effects

Chemicals

DNA, Viral Dactinomycin RNA-Directed DNA Polymerase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Zhdanov V M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/256471a0

Published

1975-08-07

Pages

471-3

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/256471a0 View journal details

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