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PMID: 5157136 Published · ppublish English Journal Article

Changes of the smooth endoplasmic reticulum induced by rifampicin in human and guinea-pig hepatocytes.

Gut ·Vol. 12 ·No. 12 ·1971-12-00 ·Pages 984-7

Jezequel AM, Orlandi F, Tenconi LT

Abstract

Rifampicin induces a proliferation of the smooth endoplasmic reticulum in guinea-pig and human hepatocytes. This may support the hypothesis of enhancement of drug-metabolizing enzymes induced by the drug. However, the pattern of proliferation is not similar in man and in guinea-pig hepatocytes. Some caution is needed in the study of enzyme induction in man and in extrapolations from animal to human data.

MeSH Terms
Animals Biotransformation Cytoplasm Endoplasmic Reticulum/drug effects,enzymology Enzyme Induction Glycogen Guinea Pigs Humans Liver/cytology,drug effects Microscopy, Electron Mitochondria, Liver Rifampin/pharmacology
Chemicals
Glycogen Rifampin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jezequel A M
Orlandi F
Tenconi L T
References (12)
12 references, click to expand
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.12.12.984
Published
1971-12-00
Pages
984-7
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1412001
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.12.12.984 PMC Full Text View journal details
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