On fibrinolysis in diabetes mellitus.

Acta medica Scandinavica ·Vol. 198 ·No. 1-2 ·1975-00-00 ·Pages 101-6

Almér LO, Nilsson IM

Abstract

In diabetics, irrespective of age at onset and standing of the disease, the fibrinolytic activity in the blood is decreased, most markedly in obese patients and in those with angiopathy. In this investigation we found--significantly more often than in controls--a low release of the plasminogen activator to the blood from the endothelial cells, and also in one fourth of the diabetics an abnormally low activator activity of the vessel walls. These changes, as well as the significantly elevated levels of inhibitors of the fibrinolytic activity, will impair removal of fibrin deposits and possibly contribute to the development of vascular lesions.

MeSH Terms

Adolescent Adult Blood Pressure Child Child, Preschool Cholesterol/blood Diabetes Mellitus/blood Diabetic Angiopathies/metabolism Female Fibrin/metabolism Fibrin Fibrinogen Degradation Products/analysis Fibrinogen/metabolism Fibrinolysis Humans Infant Infant, Newborn Male Middle Aged Plasminogen/metabolism Plasminogen Activators/metabolism Smoking Triglycerides/blood Urokinase-Type Plasminogen Activator/antagonists & inhibitors alpha-Macroglobulins/analysis

Chemicals

Fibrin Fibrinogen Degradation Products Triglycerides alpha-Macroglobulins Fibrin Fibrinogen Plasminogen Cholesterol Plasminogen Activators Urokinase-Type Plasminogen Activator

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Almér L O

Nilsson I M

Article Info

Journal

Acta medica Scandinavica

Abbr.

Acta Med Scand

ISSN

0001-6101

DOI

10.1111/j.0954-6820.1975.tb19512.x

Published

1975-00-00

Pages

101-6

Language

English

Region

Sweden

NLM ID

0370330

Subset

External Links

PubMed source DOI: 10.1111/j.0954-6820.1975.tb19512.x View journal details

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On fibrinolysis in diabetes mellitus.

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