The mast cells of the newborn rat diaphragm and their response to histamine liberators.

Agents and actions ·Vol. 5 ·No. 1 ·1975-02-00 ·Pages 48-51

Dunn CJ, Willoughby DA, Giroud JP

Abstract

The mast cell population of rat diaphragm was estimated between birth and adulthood and found to rise with an increase in the age of rat studied. Degranulation of these cells was observed in rats from all age groups, following treatment with compound 48/80 and dextran. The association of mast cells with the blood vessel wall in adult rat diaphragm was not observed in the comparable tissues of newborn rats. These findings are discussed in relationship to the poor vascular permeability reactions exhibited by newborn and young rats.

MeSH Terms

Aging Animals Animals, Newborn/anatomy & histology Blood Vessels/anatomy & histology Cell Count Cytoplasmic Granules/drug effects Dextrans/pharmacology Diaphragm/blood supply,cytology Histamine Release/drug effects Male Mast Cells/drug effects,metabolism,ultrastructure Rats p-Methoxy-N-methylphenethylamine/pharmacology

Chemicals

Dextrans p-Methoxy-N-methylphenethylamine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Dunn C J

Willoughby D A

Giroud J P

References (8)

8 references, click to expand

Cobalt ion action on the vascular permeability and mast cells of the rat.
J Pharm Pharmacol. 1969 Oct;21(10):709-10 PMID: 4390621
Relation between diaphragmatic mast-cell activity and exudate formation in acute experimental pleurisy.
J Pathol. 1971 Aug;104(4):275-81 PMID: 5135661
The response of the newborn rat to injury. I. Vascular and humoral aspects.
J Pathol. 1975 Jul;116(3):165-81 PMID: 1195051
HISTAMINE AND MAST CELLS IN HUMAN FETAL SKIN.
Proc Soc Exp Biol Med. 1964 Oct;117:63-5 PMID: 14219960
Histamine, 5-hydroxytryptamine and serum globulins in the foetal and neo-natal rat.
J Physiol. 1959 Jun 23;147(1):144-52 PMID: 13673392
Contribution to the question of the genesis of Ehrlich mast cells.
Acta Anat (Basel). 1946;2(1):40-56 PMID: 20292308
TISSUE MAST CELLS AND ACUTE INFLAMMATION IN EXPERIMENTAL CUTANEOUS MUCORMYCOSIS OF NORMAL, 48/80-TREATED, AND DIABETIC RATS.
J Exp Med. 1960 Nov 30;112(6):1069-84 PMID: 19867183
RELEASE PROCESSES IN MAST CELLS AND THEIR ACTIVATION BY INJURY.
Ann N Y Acad Sci. 1964 Aug 27;116:880-90 PMID: 14212861

Article Info

Journal

Agents and actions

Abbr.

Agents Actions

ISSN

0065-4299

DOI

10.1007/BF02027158

Published

1975-02-00

Pages

48-51

Language

English

Region

Switzerland

NLM ID

0213341

Subset

External Links

PubMed source DOI: 10.1007/BF02027158

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The mast cells of the newborn rat diaphragm and their response to histamine liberators.

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