Home LiteratureArticle Details
PMID: 5248823 Published · ppublish English Journal Article

Reduction and specific alkylation of the receptor for acetylcholine.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 60 ·No. 2 ·1968-06-00 ·Pages 668-74

Karlin A, Winnik M

Abstract

暂无摘要

MeSH Terms
Acetylcholine Alkylating Agents/pharmacology Alkylation Animals Binding Sites Eels Electric Organ/drug effects Ethylmaleimide/pharmacology Hexamethonium Compounds/pharmacology Oxidation-Reduction Receptors, Drug
Chemicals
Alkylating Agents Hexamethonium Compounds Receptors, Drug Acetylcholine Ethylmaleimide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Karlin A
Winnik M
References (21)
21 references, click to expand
  1. Evolution of structure and function of proteases.
    Science. 1967 Dec 29;158(3809):1638-44 PMID: 4862530
  2. Affinity labeling of the acetylcholine-receptor.
    Proc Natl Acad Sci U S A. 1967 Nov;58(5):2063-70 PMID: 5237500
  3. On the excitability and cooperativity of the electroplax membrane.
    Proc Natl Acad Sci U S A. 1968 Mar;59(3):944-50 PMID: 5238676
  4. Covalent labeling of active sites.
    Adv Protein Chem. 1967;22:1-54 PMID: 4883055
  5. Dibenamine blockade in strips of rabbit aorta and its use in differentiating receptors.
    J Pharmacol Exp Ther. 1954 Jul;111(3):265-84 PMID: 13175108
  6. An isolated single electroplax preparation. II. Improved preparation for studying ion flux.
    Biochim Biophys Acta. 1957 Dec;26(3):585-96 PMID: 13499417
  7. Tissue sulfhydryl groups.
    Arch Biochem Biophys. 1959 May;82(1):70-7 PMID: 13650640
  8. On the permeability of end-plate membrane during the action of transmitter.
    J Physiol. 1960 Nov;154:52-67 PMID: 13774972
  9. DITHIOTHREITOL, A NEW PROTECTIVE REAGENT FOR SH GROUPS.
    Biochemistry. 1964 Apr;3:480-2 PMID: 14192894
  10. On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine.
    J Theor Biol. 1967 Aug;16(2):306-20 PMID: 6048545
  11. Permeability and internal concentration of ions during depolarization of the electroplax.
    Proc Natl Acad Sci U S A. 1967 Sep;58(3):1162-7 PMID: 5233842
  12. The basic trypsin inhibitor of bovine pancreas. VII. Reduction with borohydride of disulfide bond linking half-cystine residues 14 and 38.
    J Biol Chem. 1967 Nov 10;242(21):4925-9 PMID: 6058936
  13. Sulfur and selenium isologs related to acetycholine. and choline IV. Activity in the electroplax preparation.
    Biochem Pharmacol. 1966 Feb;15(2):187-93 PMID: 5943319
  14. Difference in the chemical reactivity of the disulfide bonds of trypsin and chymotrypsin.
    J Biol Chem. 1967 Mar 25;242(6):1358-9 PMID: 6023577
  15. Effects of blocking sulfhydryl groups and of reducing disulfide bonds on the acetylcholine-activated permeability system of the electroplax.
    Biochim Biophys Acta. 1966 Nov 8;126(3):525-35 PMID: 5965273
  16. An alkylating derivative of benzilylcholine with specific and long-lasting parasympatholytic activity.
    Mol Pharmacol. 1966 Jul;2(4):284-97 PMID: 6007841
  17. Kinetics of the reaction of N-ethylmaleimide with cysteine and some congeners.
    Arch Biochem Biophys. 1966 Sep 9;115(3):593-7 PMID: 5970483
  18. Similarities between active sites of acetylcholine receptor and acetylcholinesterase tested with quinolinium ions.
    Proc Natl Acad Sci U S A. 1966 Sep;56(3):1034-9 PMID: 5230177
  19. Thioredoxin. A localized conformational change accompanying reduction of the protein to the sulfhydryl form.
    Biochemistry. 1967 Apr;6(4):1016-20 PMID: 4382243
  20. Chemical distinctions between acetylcholinesterase and the acetylcholine receptor.
    Biochim Biophys Acta. 1967 Jul 11;139(2):358-62 PMID: 6034678
  21. Blockade by hexamethonium of drug-induced neuromuscular facilitation.
    Arch Int Pharmacodyn Ther. 1967 May;167(1):1-9 PMID: 6035097
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.60.2.668
Published
1968-06-00
Pages
668-74
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC225098
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.60.2.668 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2