On the conformational instability of human serum low-density lipoprotein: effect of temperature.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 62 ·No. 1 ·1969-01-00 ·Pages 171-8

Scanu A, Pollard H, Hirz R, Kothary K

Abstract

When examined by circular dichroism and ultraviolet spectroscopy, human serum low-density lipoprotein (LDL) and its delipidated product, apo LDL, exhibited reversible thermal changes. The more marked temperature sensitivity of apo LDL as compared to LDL was taken to support a constraining role by lipids on the observed structural instability of the apoprotein.

MeSH Terms

Chemical Phenomena Chemistry Humans Lipids/analysis Lipoproteins/blood Spectrum Analysis Temperature

Chemicals

Lipids Lipoproteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Scanu A

Pollard H

Hirz R

Kothary K

References (14)

14 references, click to expand

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Biochem Biophys Res Commun. 1967 Apr 20;27(2):209-16 PMID: 6035486
The protein moiety of human serum beta-lipoproteins.
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Proc Natl Acad Sci U S A. 1968 Mar;59(3):890-4 PMID: 5238669
Human serum low-density lipoprotein protein: its conformation studied by circular dichroism.
Nature. 1968 Apr 13;218(5137):200-1 PMID: 5645299
Properties of human serum low density lipoproteins after modification by succinic anhydride.
J Lipid Res. 1968 May;9(3):342-9 PMID: 5650928
Human serum beta-lipoprotein: preparation and properties of a delipidated, soluble derivative.
Biochem Biophys Res Commun. 1968 Apr 19;31(2):151-7 PMID: 4968471
The structure and properties of human beta-lipoprotein and beta-apoprotein.
Biochem Biophys Res Commun. 1968 Jun 10;31(5):699-705 PMID: 4969860
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Annu Rev Biochem. 1968;37:437-62 PMID: 4877057
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.62.1.171

Published

1969-01-00

Pages

171-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC285970

Subset

External Links

PubMed source DOI: 10.1073/pnas.62.1.171 PMC Full Text View journal details

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On the conformational instability of human serum low-density lipoprotein: effect of temperature.

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