Amino acid sequence restriction in rabbit antibody light chains.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 63 ·No. 3 ·1969-07-00 ·Pages 890-6

Hood L, Lackland H, Eichman K, Kindt TJ, Braun DG, Krause RM

Abstract

Light chains were obtained from IgG rabbit antibodies to the group-specific carbohydrates of groups A and C streptococci. An analysis of the amino acid alternatives which exist at the first three positions of the N-terminus in both light-chain preparations shows a marked restriction in amino acid sequence heterogeneity when compared with preimmune light chains. Both of these related, but immunologically distinct, antigenic determinants select the same uncommon subpopulation of rabbit light chains.

MeSH Terms

Amino Acid Sequence Animals Antibody Formation Cell Wall Immunoelectrophoresis Immunoglobulin G/analysis Polysaccharides, Bacterial Rabbits Streptococcus/immunology

Chemicals

Immunoglobulin G Polysaccharides, Bacterial

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Hood L

Lackland H

Eichman K

Kindt T J

Braun D G

Krause R M

References (15)

15 references, click to expand

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Nature. 1967 Apr 29;214(5087):449-52 passim PMID: 6032862
Chemical and immunochemical evidence for different classes of rabbit light polypeptide chains.
Proc Natl Acad Sci U S A. 1968 Jul;60(3):975-81 PMID: 4970115
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Science. 1969 Feb 14;163(3868):633-44 PMID: 4178710
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.63.3.890

Published

1969-07-00

Pages

890-6

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC223536

Subset

External Links

PubMed source DOI: 10.1073/pnas.63.3.890 PMC Full Text View journal details

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Amino acid sequence restriction in rabbit antibody light chains.

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