Na plus-facilitated reactions of neutral amino acids with a cationic amino acid transport system.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 63 ·No. 3 ·1969-07-00 ·Pages 948-55

Christensen HN, Handlogten ME, Thomas EL

Abstract

The predominant basis for transport interactions between neutral and cationic amino acids in the Ehrlich ascites-tumor cell and the rabbit reticulocyte has been identified as a reaction of the neutral amino acid plus Na(+) with the cationic amino acid transport system. This reaction is revealed both by a Na(+)-dependent transport inhibition by the neutral amino acid, and by mutual flux accelerations whereby the neutral amino acid and Na(+) exchange for the cationic amino acid.

MeSH Terms

Amino Acids Animals Biological Transport Carbon Isotopes Carcinoma, Ehrlich Tumor/metabolism Culture Techniques Hydrogen-Ion Concentration Reticulocytes/metabolism Sodium/pharmacology

Chemicals

Amino Acids Carbon Isotopes Sodium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Christensen H N

Handlogten M E

Thomas E L

References (17)

17 references, click to expand

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Interdependent fluxes of amino acids and sodium ion in the pigeon red blood cell.
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A distinct Na+-requiring transport system for alanine, serine, cysteine, and similar amino acids.
J Biol Chem. 1967 Nov 25;242(22):5237-46 PMID: 6070848
Homo- and hetero-exchange diffusion of amino acids in Ehrlich ascites carcinoma cells.
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Modes of mediated exodus of amino acids from the Ehrlich ascites tumor cell.
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Cationic amino acid transport in the rabbit reticulocyte. Na+-dependent inhibition of Na+-independent transport.
J Biol Chem. 1969 Mar 25;244(6):1497-504 PMID: 5773053
A bicyclic amino acid to improve discriminations among transport systems.
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Some special kinetic problems of transport.
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Effect of infusion of single amino acids upon excretion of other amino acids.
Am J Physiol. 1951 Mar;164(3):654-61 PMID: 14819283
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.63.3.948

Published

1969-07-00

Pages

948-55

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC223544

Subset

External Links

PubMed source DOI: 10.1073/pnas.63.3.948 PMC Full Text View journal details

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Na plus-facilitated reactions of neutral amino acids with a cationic amino acid transport system.

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