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PMID: 525991 Published · ppublish English Comparative Study Journal Article

Effectiveness of nafcillin, methicillin, and cephalothin in experimental Staphylococcus aureus endocarditis.

Antimicrobial agents and chemotherapy ·Vol. 15 ·No. 5 ·1979-05-00 ·Pages 735-7

Carrizosa J, Kobasa WD, Kaye D

Abstract

Nafcillin, methicillin, and cephalothin (40 mg/kg every 6 h) were all effective in reducing the number of Staphylococcus aureus in vegetations in rabbits with endocarditis. Nafcillin and methicillin reduced the number of S. aureus at a significantly faster rate than did cephalothin. Nafcillin and methicillin also reduced titers of the S. aureus more rapidly than did cephalothin in vitro, both in broth and in rabbit serum.

MeSH Terms
Animals Cephalothin/blood,therapeutic use Endocarditis, Bacterial/drug therapy Female Methicillin/blood,therapeutic use Nafcillin/blood,therapeutic use Rabbits Staphylococcal Infections/drug therapy Time Factors
Chemicals
Nafcillin Methicillin Cephalothin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Carrizosa J
Kobasa W D
Kaye D
References (5)
5 references, click to expand
  1. IN VITRO AND IN VIVO LABORATORY EVALUATION OF CEPHALOGLYCIN AND CEPHALORIDINE.
    Appl Microbiol. 1965 Mar;13:248-53 PMID: 14325888
  2. Treatment of experimental Staphylococcus aureus endocarditis: comparison of cephalothin, cefazolin, and methicillin.
    Antimicrob Agents Chemother. 1978 Jan;13(1):74-7 PMID: 626493
  3. Antibiotic synergism in enterococcal endocarditis.
    J Lab Clin Med. 1976 Jul;88(1):132-41 PMID: 819602
  4. Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens.
    J Clin Invest. 1973 Mar;52(3):592-8 PMID: 4685083
  5. Pharmacology of cefazolin in patients with normal and abnormal renal function.
    J Infect Dis. 1973 Oct;128:Suppl:S354-7 PMID: 4744017
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.15.5.735
Published
1979-05-00
Pages
735-7
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC352746
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.15.5.735 PMC Full Text View journal details
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