A mechanism for genetic recombination generating one parent and one recombinant.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 64 ·No. 2 ·1969-10-00 ·Pages 573-7

Boon T, Zinder ND

Abstract

A mechanism is proposed for generating one parental and one recombinant genome in a single recombination event between two DNA molecules. Three stages of the event are described: initiation, replication, and return. Initiation requires breakage and joining of strands. Replication proceeds through a biparental "replication fork" generated in initiation. Return also involves breakage and joining of strands. Some of the implications of such a mechanism for genetic recombination are discussed.

MeSH Terms

Bacteriophages Chromosomes DNA Replication DNA, Viral Models, Biological Recombination, Genetic

Chemicals

DNA, Viral

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Boon T

Zinder N D

References (19)

19 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.64.2.573

Published

1969-10-00

Pages

573-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC223382

Subset

External Links

PubMed source DOI: 10.1073/pnas.64.2.573 PMC Full Text View journal details

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A mechanism for genetic recombination generating one parent and one recombinant.

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