The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 64 ·No. 1 ·1969-09-00 ·Pages 161-7

Thomson DM, Krupey J, Freedman SO, Gold P

Abstract

A radioimmunoassay has been developed for determining the serum levels of carcinoembryonic antigen of the human digestive system in patients with cancer of the colon and rectum. The assay is simple to perform and has a high degree of reproducibility and specificity. The test detects a concentration of 2.5 ng of carcinoembryonic antigen per ml of serum and this has provided the first demonstration of a circulating tumor-specific antigen in the sera of cancer patients.

MeSH Terms

Adenocarcinoma/blood,immunology Antigens/analysis Autoradiography Humans Immunoelectrophoresis Intestinal Neoplasms/blood,immunology Iodine Radioisotopes Methods Neoplasm Metastasis/immunology Radioimmunoassay Serologic Tests

Chemicals

Antigens Iodine Radioisotopes

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Thomson D M

Krupey J

Freedman S O

Gold P

References (7)

7 references, click to expand

A radio-immunoelectrophoretic assay for human growth hormone.
Biochem J. 1964 Apr;91(1):43-56 PMID: 4953593
Specific carcinoembryonic antigens of the human digestive system.
J Exp Med. 1965 Sep 1;122(3):467-81 PMID: 4953873
Cellular location of carcinoembryonic antigens of the human digestive system.
Cancer Res. 1968 Jul;28(7):1331-4 PMID: 4874989
Physicochemical studies of the carcinoembryonic antigens of the human digestive system.
J Exp Med. 1968 Sep 1;128(3):387-98 PMID: 4299103
A quantitative immunochemical measure of the primary interaction between I BSA and antibody.
J Infect Dis. 1958 Nov-Dec;103(3):239-62 PMID: 13611294
DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES.
J Exp Med. 1965 Mar 1;121:439-62 PMID: 14270243
Immunoassay of endogenous plasma insulin in man.
J Clin Invest. 1960 Jul;39:1157-75 PMID: 13846364

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.64.1.161

Published

1969-09-00

Pages

161-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC286141

Subset

External Links

PubMed source DOI: 10.1073/pnas.64.1.161 PMC Full Text View journal details

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The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system.

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