A clonal analysis of determination in Antennapedia a homoeotic mutant of Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 64 ·No. 1 ·1969-09-00 ·Pages 176-83

Postlethwait JH, Schneiderman HA

Abstract

The process by which cells select one of several specific programs of genetic information in development was examined in homoeotic mutant Antennapedia of Rappaport in Drosophila melanogaster. The results show that the alteration of determination from antenna to leg induced by this homoeotic mutation occurs in a population of cells related by proximity rather than by pedigree. Clones of cells marked by means of X-ray-induced somatic crossing-over prior to early third instar participated in the formation of both antenna and homoeotic leg, but after this time, the clone was restricted to either antenna or homoeotic leg, indicating that determination occurs in the third larval instar. The results are discussed in relation to other processes of determination.

MeSH Terms

Animals Clone Cells Crossing Over, Genetic Drosophila Genetic Code Mutation Radiation Genetics Selection, Genetic

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Postlethwait J H

Schneiderman H A

References (13)

13 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.64.1.176

Published

1969-09-00

Pages

176-83

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC286144

Subset

External Links

PubMed source DOI: 10.1073/pnas.64.1.176 PMC Full Text View journal details

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A clonal analysis of determination in Antennapedia a homoeotic mutant of Drosophila melanogaster.

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