Sympathetic nerve cell destruction in newborn mammals by 6-hydroxydopamine.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 65 ·No. 1 ·1970-01-00 ·Pages 114-21

Angeletti PU, Levi-Montalcini R

Abstract

A selective and permanent destruction of sympathetic ganglia was achieved by injecting 6-hydroxydopamine in newborn animals. A lifelong chemical sympathectomy may thus be obtained. The process of cell damage and destruction is substantially different from that produced with an antiserum to a specific nerve growth factor.

MeSH Terms

Animals Animals, Newborn Catecholamines/pharmacology Dopamine Ganglia, Autonomic/cytology,drug effects Mice Microscopy, Electron Nerve Growth Factors/pharmacology Phenethylamines/pharmacology Rats Sympathetic Nervous System/drug effects

Chemicals

Catecholamines Nerve Growth Factors Phenethylamines Dopamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Angeletti P U

Levi-Montalcini R

References (14)

14 references, click to expand

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Alterations in the fine structure of nucleoli in sympathetic neurons following NGF-antiserum treatment.
Brain Res. 1969 Jan;12(1):54-73 PMID: 5802485
The nerve growth factor (NGF): chemical properties and metabolic effects.
Adv Enzymol Relat Areas Mol Biol. 1968;31:51-75 PMID: 4880217
Second symposium on catecholamines. Modification of sympathetic function. Immunosympathectomy.
Pharmacol Rev. 1966 Mar;18(1):619-28 PMID: 5904173
PURIFICATION OF A NERVE-GROWTH PROMOTING PROTEIN FROM THE MOUSE SALIVARY GLAND AND ITS NEURO-CYTOTOXIC ANTISERUM.
Proc Natl Acad Sci U S A. 1960 Mar;46(3):302-11 PMID: 16578483
Effect of 6-hydroxydopamine and some other compounds on the concentration of norepinephrine in the hearts of mice.
J Pharmacol Exp Ther. 1963 Jun;140:308-16 PMID: 13972348
Recent developments on the ultrastructural aspect of adrenergic nerve endings in various experimental conditions.
Prog Brain Res. 1969;31:33-46 PMID: 4900115
EXCESSIVE GROWTH OF THE SYMPATHETIC GANGLIA EVOKED BY A PROTEIN ISOLATED FROM MOUSE SALIVARY GLANDS.
Proc Natl Acad Sci U S A. 1960 Mar;46(3):373-84 PMID: 16578496
Immunochemical properties of the nerve growth factor.
Proc Natl Acad Sci U S A. 1968 Nov;61(3):835-42 PMID: 4972013
The nerve growth factor: its mode of action on sensory and sympathetic nerve cells.
Harvey Lect. 1966;60:217-59 PMID: 5338067
An electron microscopic study of selective, acute degeneration of sympathetic nerve terminals after administration of 6-hydroxydopamine.
Experientia. 1968 Feb 15;24(2):155-6 PMID: 4384505
Chemical sympathectomy by selective destruction of adrenergic nerve endings with 6-Hydroxydopamine.
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1968;261(3):271-88 PMID: 4387076
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.65.1.114

Published

1970-01-00

Pages

114-21

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC286199

Subset

External Links

PubMed source DOI: 10.1073/pnas.65.1.114 PMC Full Text View journal details

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Sympathetic nerve cell destruction in newborn mammals by 6-hydroxydopamine.

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