Analysis of a model for active transport.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 65 ·No. 2 ·1970-02-00 ·Pages 409-16

Hill TL

Abstract

A particular model of active transport is analyzed, at steady state, by means of a diagram method for the kinetics, and supplemented by use of a free energy diagram. It is assumed that there is cyclic adsorption of adenosine triphosphate (ATP), chemical reaction to adenosine diphosphate (ADP), and desorption of ADP, on a two-state protein (the "carrier"). ATP is the "effector" for the change in state of the protein.

MeSH Terms

Adenine Nucleotides/metabolism Adenosine Triphosphate/metabolism Biological Transport, Active Cell Membrane Kinetics Models, Biological Proteins/metabolism

Chemicals

Adenine Nucleotides Proteins Adenosine Triphosphate

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Hill T L

References (2)

2 references, click to expand

A proposed common allosteric mechanism for active transport, muscle contraction, and ribosomal translocation.
Proc Natl Acad Sci U S A. 1969 Sep;64(1):267-74 PMID: 5263010
The free-energy changes associated with the individual steps of the tricarboxylic acid cycle, glycolysis and alcoholic fermentation and with the hydrolysis of the pyrophosphate groups of adenosinetriphosphate.
Biochem J. 1953 Apr;54(1):94-107 PMID: 13058838

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.65.2.409

Published

1970-02-00

Pages

409-16

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC282918

Subset

External Links

PubMed source DOI: 10.1073/pnas.65.2.409 PMC Full Text View journal details

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