Cooperative effects in models of steady-state transport across membranes. 3. Simulation of potassium ion transport in nerve.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 66 ·No. 3 ·1970-07-00 ·Pages 607-14

Hill TL, Chen Y

Abstract

An extremely simple membrane transport model simulates qualitatively the observed flux-potential curves for steady-state potassium ion transport across a nerve (squid) membrane in the special case of high external potassium ion concentration. The transporting units (protein molecules) in the model are assumed to exist in two different conformations, which interact cooperatively. The membrane potential induces a transition between the two conformations by virtue, primarily, of a polarizability difference in the two conformations. Differential proton binding may make an important contribution to this effect.

MeSH Terms

Biological Transport Cell Membrane/physiology Membrane Potentials Models, Neurological Nerve Tissue Proteins Neurons/physiology Potassium/metabolism

Chemicals

Nerve Tissue Proteins Potassium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hill T L

Chen Y

References (4)

4 references, click to expand

Electric fields and the cooperativity of biological membranes.
Proc Natl Acad Sci U S A. 1967 Jul;58(1):111-4 PMID: 5231590
Cooperative effects in models of steady-state transport across membranes. II. Oscillating phase transition.
Proc Natl Acad Sci U S A. 1970 May;66(1):189-96 PMID: 5273896
Excitation of the squid axon membrane in isosmotic potassium chloride.
Nature. 1959 Jan 24;183(4656):265-6 PMID: 13622770
The Influence of Dipole Moment Fluctuations on the Dielectric Increment of Proteins in Solution.
Proc Natl Acad Sci U S A. 1952 Oct;38(10):855-62 PMID: 16589189

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.66.3.607

Published

1970-07-00

Pages

607-14

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC283093

Subset

External Links

PubMed source DOI: 10.1073/pnas.66.3.607 PMC Full Text View journal details

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Cooperative effects in models of steady-state transport across membranes. 3. Simulation of potassium ion transport in nerve.

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