Biological membrane structure, I. The protein crystal model for membranes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 66 ·No. 3 ·1970-07-00 ·Pages 615-21

Vanderkooi G, Green DE

Abstract

A geometric model for the arrangement of phospholipid and protein in biological membrane systems has been proposed. The essential principle underlying this model is that when membrane proteins polymerize, the points of contact between proteins are few, and cavities lined with predominantly nonpolar amino acids are formed. Phospholipid molecules become oriented with the fatty chains inserted into the cavities while the polar heads remain on the surface of the membrane. This orientation applies to both faces of the membrane continuum. All the lipid known to be present in membranes can be accommodated in this manner. The body of evidence supporting this model has been presented.

MeSH Terms

Crystallography Cytochromes Membranes Mitochondria Models, Structural Phospholipids Proteins

Chemicals

Cytochromes Phospholipids Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Vanderkooi G

Green D E

References (29)

29 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.66.3.615

Published

1970-07-00

Pages

615-21

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC283094

Subset

External Links

PubMed source DOI: 10.1073/pnas.66.3.615 PMC Full Text View journal details

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Biological membrane structure, I. The protein crystal model for membranes.

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