Effect of sodium ions on calcium movements in isolated synaptic terminals.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 66 ·No. 3 ·1970-07-00 ·Pages 664-71

Blaustein MP, Wiesmann WP

Abstract

Calcium accumulation has been studied in isolated presynaptic nerve terminals from rat brain. Calcium influx is increased when external sodium is replaced by lithium or choline, or when the internal sodium concentration is increased by treatment with ouabain. Calcium efflux is reduced when external sodium is replaced by lithium. The lithium-stimulated calcium accumulation appears to be associated with the nerve terminals, and not with mitochondria or membrane fragments. It is dependent upon an osmotically sensitive surface membrane. The results are consistent with the hypothesis that calcium is actively extruded from mammalian central neurons by a mechanism which exchanges calcium for sodium, and which derives its energy from the sodium concentration gradient.

MeSH Terms

Animals Biological Transport, Active Brain/cytology,metabolism Calcium/metabolism Calcium Isotopes Centrifugation, Density Gradient Choline/pharmacology Lithium/pharmacology Nerve Endings/cytology,metabolism Osmotic Pressure Ouabain/pharmacology Rats Sodium/physiology Synapses/metabolism

Chemicals

Calcium Isotopes Ouabain Lithium Sodium Choline Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Blaustein M P

Wiesmann W P

References (16)

16 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.66.3.664

Published

1970-07-00

Pages

664-71

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC283102

Subset

External Links

PubMed source DOI: 10.1073/pnas.66.3.664 PMC Full Text View journal details

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Effect of sodium ions on calcium movements in isolated synaptic terminals.

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