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PMID: 5271167 Published · ppublish English Journal Article

Linkage between the poly-L-lysine gene and the locus controlling the major histocompatibility antigens in strain 2 guinea pigs.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 66 ·No. 2 ·1970-06-00 ·Pages 322-8

Ellman L, Green I, Martin WJ, Benacerraf B

Abstract

The data presented demonstrate linkage between the major histocompatibility locus of inbred strain 2 guinea pigs and a "specific immune response gene," the PLL gene, which controls responsiveness to poly-L-lysine and hapten conjugates of this polypeptide in these animals. This finding extends to another species and to a different immune system the linkage observed in mice between the H(2) locus and specific immune response genes at the Ir-1 locus. The general significance of the linkage of specific immune response genes to histocompatibility loci is discussed.

MeSH Terms
Animals Antibody Formation Antigen-Antibody Reactions Antigens/analysis Cattle Chromium Isotopes Crosses, Genetic Female Genes Genes, Regulator Guinea Pigs Histocompatibility Immune Tolerance Leukocytes/immunology Lysine Male Polymers Species Specificity Tritium
Chemicals
Antigens Chromium Isotopes Polymers Tritium Lysine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ellman L
Green I
Martin W J
Benacerraf B
References (18)
18 references, click to expand
  1. Genetic control of the antibody response. I. Demonstration of determinant-specific differences in response to synthetic polypeptide antigens in two strains of inbred mice.
    J Exp Med. 1965 Sep 1;122(3):517-31 PMID: 5839284
  2. Antigenicity of polypeptides (poly alpha amino acids). XVI. Genetic control of immunogenicity of synthetic polypeptides in mice.
    J Exp Med. 1965 Oct 1;122(4):673-9 PMID: 5849233
  3. Mouse thymic iso-antigens.
    Nature. 1966 Jan 29;209(5022):521-3 PMID: 5919593
  4. The immune response to a hybrid protein molecule; specificity of secondary stimulation and of tolerance induction.
    J Exp Med. 1967 Oct 1;126(4):581-606 PMID: 6055758
  5. Genetic control of the antibody response in inbred mice. Transfer of response by spleen cells and linkage to the major histocompatibility (H-2) locus.
    J Exp Med. 1968 Jul 1;128(1):1-11 PMID: 5662015
  6. Studies on synthetic polypeptide antigens. XX. Genetic control of the antibody response in the rat to structurally different synthetic polypeptide antigens.
    J Immunol. 1968 Oct;101(4):730-42 PMID: 5681653
  7. Genetic control of the antibody response: relationship between immune response and histocompatibility (H-2) type.
    Science. 1969 Mar 14;163(3872):1207-8 PMID: 5765335
  8. Transfer of responsiveness to hapten conjugates of poly-L-lysine and of a copolymer of L-glutamic acid and L-lysine to lethally irradiated nonresponder guinea pigs by bone marrow or lymph node and spleen cells from responder guinea pigs.
    J Exp Med. 1969 Nov 1;130(5):1107-22 PMID: 4899853
  9. Studies on the polylysine immune responder gene. The rank order of immunogenicity of dinitrophenyl conjugates of basic homopolyamino acids in guinea pigs.
    J Immunol. 1969 Nov;103(5):931-6 PMID: 5350975
  10. Acute childhood leukaemia in relation to the HL-A human transplantation genes.
    Nature. 1970 Jan 31;225(5231):461-2 PMID: 5262706
  11. Genetic control of immunological responsiveness in guinea pigs to 2,4-dinitrophenyl conjugates of poly-L-arginine, protamine, and poly-L-ornithine.
    Proc Natl Acad Sci U S A. 1969 Nov;64(3):1095-102 PMID: 4984383
  12. Genetic control of specific immune responses.
    Adv Immunol. 1969;11:31-74 PMID: 4908392
  13. Leukemia in guinea-pigs.
    Am J Pathol. 1954 Mar-Apr;30(2):337-59 PMID: 13138713
  14. Studies on artifical antigens. I. Antigenicity of DNP-polylysine and DNP copolymer of lysine and glutamic acid in guinea pigs.
    J Exp Med. 1963 Jan 1;117:55-69 PMID: 14030666
  15. STUDIES ON ARTIFICIAL ANTIGENS. III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS.
    J Exp Med. 1963 Dec 1;118:953-7 PMID: 14112274
  16. GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKAEMOGENESIS.
    Lancet. 1964 Dec 5;2(7371):1207-9 PMID: 14215561
  17. GENETIC CONTROL IN GUINEA PIGS OF IMMUNE RESPONSE TO CONJUGATES OF HAPTENS AND POLY-L-LYSINE.
    Science. 1965 Jan 29;147(3657):517-8 PMID: 14237210
  18. CYTOTOXIC REACTIONS OF MOUSE ISOANTISERA: THE SCOPE OF AN ASSAY USING RADIOLABELLED TARGET CELLS.
    Transplantation. 1965 Jul;3:557-62 PMID: 14339514
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.66.2.322
Published
1970-06-00
Pages
322-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC283047
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.66.2.322 PMC Full Text View journal details
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