Role of adrenal cortical function in toxicity of polyriboinosinic-polyribocytidylic acid and its component homopolymers.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 67 ·No. 1 ·1970-09-00 ·Pages 180-4

Zedeck MS, Marquardt H, Sternberg SS, Fleisher M, Hamilton LD

Abstract

Adrenalectomized rats are 1000 times more sensitive to lethal effects of the double-stranded complex polyriboinosinic.polyribocytidylic acid than intact rats. They are protected from such lethal effects by corticosterone. The complex can rapidly induce diffuse, severe necrosis of villous epithelium in small intestine without damage in crypts. Injection of the individual homopolymers, polyriboinosinic acid and polyribocytidylic acid, separately but in rapid succession is at least as lethal as injection of the complex.

MeSH Terms

Adrenal Glands/physiology Adrenalectomy Animals Blood Glucose Corticosterone/pharmacology Cytosine Nucleotides/toxicity Duodenum/drug effects,pathology Male Polynucleotides/administration & dosage,antagonists & inhibitors,toxicity Rats

Chemicals

Blood Glucose Cytosine Nucleotides Polynucleotides Corticosterone

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Zedeck M S

Marquardt H

Sternberg S S

Fleisher M

Hamilton L D

References (7)

7 references, click to expand

Uptake of polynucleotides by intact mammalian cells (IV): synthetic homoribopolynucleotides.
Z Naturforsch B. 1968 Aug;23(8):1117-9 PMID: 4387618
Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.
Proc Natl Acad Sci U S A. 1967 Sep;58(3):1004-10 PMID: 5233831
Inhibition of herpes simplex virus by synthetic double-stranded RNA (polyriboadenylic and polyribouridylic acids and polyriboinosinic and polyribocytidylic acids).
Proc Natl Acad Sci U S A. 1969 Nov;64(3):878-83 PMID: 4313333
Screening steroids against a spectrum of tumors.
Ann N Y Acad Sci. 1958 Dec 5;76(3):720-8 PMID: 13627899
Fasting ketosis in the adrenalectomized and cortisone-treated rat.
Endocrinology. 1954 Nov;55(5):593-600 PMID: 13210302
Biochemical and pathological effects of methylazoxymethanol acetate, a potent carcinogen.
Cancer Res. 1970 Mar;30(3):801-12 PMID: 5425295
Inhibition of tumor growth by polyinosinic-polycytidylic acid.
Proc Natl Acad Sci U S A. 1969 Feb;62(2):357-61 PMID: 4894326

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.67.1.180

Published

1970-09-00

Pages

180-4

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC283185

Subset

External Links

PubMed source DOI: 10.1073/pnas.67.1.180 PMC Full Text View journal details

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Role of adrenal cortical function in toxicity of polyriboinosinic-polyribocytidylic acid and its component homopolymers.

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