5-bromodeoxyuridine-induced differentiation of a neuroblastoma.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 67 ·No. 1 ·1970-09-00 ·Pages 247-54

Schubert D, Jacob F

Abstract

5-Bromodeoxyuridine induces the differentiation of mouse neuroblastoma C1300 to cells that morphologically resemble mature neurons. The induced differentiation can take place in the absence of DNA synthesis. This suggests that the halogenated pyrimidine need not be incorporated into DNA to alter the phenotype of the cell.

MeSH Terms

Animals Bromodeoxyuridine/pharmacology Carbon Isotopes Cell Differentiation/drug effects Cell Division/drug effects Cell Line Colchicine/pharmacology Culture Techniques Cycloheximide/pharmacology Cytarabine/pharmacology DNA/biosynthesis Dactinomycin/pharmacology Leucine/metabolism Mice Mitomycins/pharmacology Neuroblastoma Neurons Phenotype Puromycin/pharmacology Thymidine/metabolism Tritium

Chemicals

Carbon Isotopes Mitomycins Cytarabine Tritium Dactinomycin Puromycin DNA Cycloheximide Bromodeoxyuridine Leucine Colchicine Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Schubert D

Jacob F

References (8)

8 references, click to expand

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Microtubule crystals: a new biophysical phenomenon induced by Vinca alkaloids.
Nature. 1968 Jun 22;218(5147):1176-7 PMID: 5656643
Cytoplasmic filaments and tubules.
Fed Proc. 1968 Sep-Oct;27(5):1186-93 PMID: 5673268
The effects of 5-Bromodeoxyuridine on the differentiation of chondrocytes in vitro.
Dev Biol. 1969 May;19(5):415-35 PMID: 5767844
Inhibition of myoblast fusion after one round of DNA synthesis in 5-bromodeoxyuridine.
J Cell Biol. 1970 Jan;44(1):134-50 PMID: 4242927
Actinomycin D: effects on mouse L-cells.
Biophys J. 1969 Dec;9(12):1427-45 PMID: 5357735
Acetylcholine sensitivity and distribution on mouse neuroblastoma cells.
Science. 1970 Feb 27;167(3922):1253-5 PMID: 4312553
In vitro differentiation of a mouse neuroblastoma.
Proc Natl Acad Sci U S A. 1969 Sep;64(1):316-23 PMID: 4189500

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.67.1.247

Published

1970-09-00

Pages

247-54

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC283195

Subset

External Links

PubMed source DOI: 10.1073/pnas.67.1.247 PMC Full Text View journal details

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5-bromodeoxyuridine-induced differentiation of a neuroblastoma.

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