Regulation of cellular interferon production: enhancement by antimetabolites.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 67 ·No. 1 ·1970-09-00 ·Pages 464-71

Tan YH, Armstrong JA, Ke YH, Ho M

Abstract

Cycloheximide, at a protein-inhibitory concentration, when given to rabbit kidney cell cultures that had been exposed either to UV-irradiated Newcastle Disease virus or to a complex of polyinosinic and polycytidylic acids (poly I.poly C), enhanced the production of interferon. The enhancement was greater if, in addition to cycloheximide, the cells were also treated with actinomycin D. On the basis of these findings, a mechanism, consisting primarily of the production of a control protein which normally checks interferon production, is postulated for interferons stimulated by these two substances.

MeSH Terms

Animals Antimetabolites/pharmacology Cell Line Cycloheximide/pharmacology Dactinomycin/pharmacology Interferons/biosynthesis Kidney Kinetics Metabolism/drug effects Models, Biological Newcastle disease virus/radiation effects Polynucleotides/pharmacology Protein Biosynthesis Rabbits Radiation Effects Ultraviolet Rays

Chemicals

Antimetabolites Polynucleotides Dactinomycin Interferons Cycloheximide

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Tan Y H

Armstrong J A

Ke Y H

Ho M

References (11)

11 references, click to expand

Influence of inhibitors of protein synthesis on interferon formation in mice.
Virology. 1965 Dec;27(4):541-50 PMID: 5855570
Effect of interferon treatment on interferon production.
J Immunol. 1966 May;96(5):872-7 PMID: 5913757
Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.
Proc Natl Acad Sci U S A. 1967 Sep;58(3):1004-10 PMID: 5233831
Interferon production in mice by double-stranded synthetic polynucleotides: induction or release?
Virology. 1968 May;35(1):177-9 PMID: 5652677
Interferon inducers in vitro: difference in sensitivity to inhbitiros of RNA and protein synthesis.
Science. 1968 Aug 2;161(3840):465-8 PMID: 5659681
Studies on the physico-chemical inactivation of rabbit inerferons.
Proc Soc Exp Biol Med. 1968 Nov;129(2):433-8 PMID: 4301420
Inducers of interferon and host resistance, V. In vitro studies.
Proc Natl Acad Sci U S A. 1968 Sep;61(1):340-6 PMID: 4301592
Inhibition of induction of interferon synthesis in L-cells pretreated with interferon.
Virology. 1969 Mar;37(3):473-5 PMID: 4180629
The mechanism of stimution of interferon production by a complexed polyribonucleotide.
Virology. 1970 Mar;40(3):693-702 PMID: 5437790
IDENTIFICATION AND "INDUCTION" OF INTERFERON.
Bacteriol Rev. 1964 Dec;28:367-81 PMID: 14244712
EFFECT OF ACTINOMYCIN D ON VIRUS AND ENDOTOXIN-INDUCED INTERFERONLIKE INHIBITORS IN RABBITS.
Proc Natl Acad Sci U S A. 1965 Jan;53:220-4 PMID: 14283202

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.67.1.464

Published

1970-09-00

Pages

464-71

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC283227

Subset

External Links

PubMed source DOI: 10.1073/pnas.67.1.464 PMC Full Text View journal details

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