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PMID: 5273902 Published · ppublish English Journal Article

Colony inhibition of fibroblasts from chimeric dogs mediated by the dogs' own lymphocytes and specifically abrogated by their serum.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 66 ·No. 1 ·1970-05-00 ·Pages 65-71

Hellström I, Hellström KE, Storb R, Thomas ED

Abstract

Nine canine irradiation chimeras were studied between 173 days and 7.5 years after 1200 to 1500 r of total body irradiation and transplantation of allogeneic bone marrow. Skin fibroblasts from chimeras and normal dogs were tested for colony inhibition by exposure to sera and peripheral blood lymphocytes from both chimeric and normal dogs. Lymphocytes from the chimeric dog were found to inhibit colony formation by its "own" fibroblasts while lymphocytes from other chimeras or from normal dogs did not. Serum from the chimera specifically abrogated this inhibitory effect. These results indicate that the immunological "tolerance" of the chimeric dog is mediated in vivo by blocking serum factors.

MeSH Terms
Animals Antigen-Antibody Reactions Antigens Dogs Fibroblasts/immunology Immune Tolerance Lymphocytes/immunology Radiation Chimera Skin/cytology
Chemicals
Antigens
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Hellström I
Hellström K E
Storb R
Thomas E D
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23 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.66.1.65
Published
1970-05-00
Pages
65-71
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286088
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.66.1.65 PMC Full Text View journal details
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