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PMID: 5274468 Published · ppublish English Journal Article

Amino acid sequence of the basic protein of the myelin membrane.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 67 ·No. 3 ·1970-11-00 ·Pages 1425-31

Eylar EH

Abstract

The amino acid sequences of the encephalitogenic basic protein, A1, from bovine and human myelin are similar, differing by only 11 residues. The sequence reveals that while basic residues are spread randomly over most of the polypeptide chain, several regions (8-10 residues) exist that are nonpolar in character. The bovine protein has 170 residues with molecular weight 18,400. The human protein, which has an additional His-Gly sequence, contains 172 residues. The major encephalitogenic determinant (tryptophan region) of the bovine protein differs from the human only by a lysine to arginine substitution. The structural features of the A1 protein are discussed, with special reference to its role in stabilization of the myelin membrane, and its relation to multiple sclerosis.

MeSH Terms
Amino Acid Sequence Animals Cattle Chromatography, Gel Electrophoresis Encephalomyelitis, Autoimmune, Experimental/etiology Humans Molecular Weight Myelin Sheath Peptides/analysis Species Specificity
Chemicals
Peptides
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Eylar E H
References (25)
25 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.67.3.1425
Published
1970-11-00
Pages
1425-31
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC283369
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.67.3.1425 PMC Full Text View journal details
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