Separate transport systems for sugars and amino acids in developing rat kidney cortex.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 2 ·1971-02-00 ·Pages 372-6

Segal S, Rea C, Smith I

Abstract

The ability of renal cortical slices of newborn and young rats to accumulate a nonmetabolizable sugar, alpha-methylglucoside, is slight and does not reach adult capacity until 25 days of age. However, a rudimentary sugar transport system is present, as indicated by a further decrease in accumulation in the presence of phlorizin or absence of sodium ion.Amino acid uptake in immature kidney tissue is not deficient; on the contrary, the tissue took up and concentrated more glycine and lysine than adult tissue. Decreased amino acid efflux from the immature cells appears to be the explanation. Concentration dependence of amino acid uptake was the same in 5-day-old and adult tissue. These differences between the transport characteristics of a model sugar and representative amino acids during development indicate separate transport systems for the two types of substrate.

MeSH Terms

Amino Acids/metabolism Animals Animals, Newborn Biological Transport

Chemicals

Amino Acids

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Segal S

Rea C

Smith I

References (26)

26 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.2.372

Published

1971-02-00

Pages

372-6

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC388940

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.2.372 PMC Full Text View journal details

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Separate transport systems for sugars and amino acids in developing rat kidney cortex.

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