Linkage disequilibrium in a local population of Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 5 ·1971-05-00 ·Pages 1065-9

Mukai T, Mettler LE, Chigusa SI

Abstract

461 second chromosomes of Drosophila melanogaster were extracted from a Raleigh, N.C. population and four enzymes controlled by the genes located in this chromosome (alcohol dehydrogenase (EC 1.1.1.1.), malate dehydrogenase-1 (EC 1.1.1.37), glycerol-3-phosphate dehydrogenase-1 (EC 1.1.1.8), and alpha-amylase (EC 3.2.1.1), were assayed electrophoretically and cytologically (salivary-gland chromosomes). Linkage disequilibrium could not be detected among any pair of isozyme genes, except in one case that is best explained as due to a chance error in estimation. Some disequilibria were detected, however, between isozyme genes and polymorphic inversions. The relative viabilities of homozygous and heterozygous combinations of these chromosomes were estimated with respect to the alcohol dehydrogenase alleles and the glycerol-3-phosphate dehydrogenase alleles; no significant difference could be detected. The role of epistasis in natural populations is discussed on the basis of these results.

MeSH Terms

Alcohol Oxidoreductases/analysis Alleles Amylases/analysis Animals Chromosomes/analysis Drosophila/metabolism Electrophoresis Gene Frequency Genes Genetic Linkage Glycerolphosphate Dehydrogenase/analysis Heterozygote Homozygote Isoenzymes/analysis Malate Dehydrogenase/analysis Polymorphism, Genetic Salivary Glands/cytology

Chemicals

Isoenzymes Alcohol Oxidoreductases Glycerolphosphate Dehydrogenase Malate Dehydrogenase Amylases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Mukai T

Mettler L E

Chigusa S I

References (14)

14 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.5.1065

Published

1971-05-00

Pages

1065-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC389114

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.5.1065 PMC Full Text View journal details

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Linkage disequilibrium in a local population of Drosophila melanogaster.

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