Synthesis of amplified DNA that codes for ribosomal RNA.
During the amplification stage in ovaries, the complete repetitive unit of the DNA that codes for ribosomal RNA in Xenopus appears to be transcribed. This large RNA transcript is found in a complex with DNA. Substitution experiments with 5-bromodeoxyuridine do not show any evidence that a complete amplified cistron is used as a template for further amplification. A derivative of rifampicin, 2',5'-dimethyl-N(4')benzyl-N(4')[desmethyl] rifampicin, preferentially inhibits the DNA synthesis responsible for ribosomal gene amplification. These results are consistent with the hypothesis that RNA-dependent DNA synthesis is involved in gene amplification.
18 references, click to expand
-
A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membrane.J Mol Biol. 1965 Jul;12(3):829-42 PMID: 4955314
-
Specific gene amplification in oocytes. Oocyte nuclei contain extrachromosomal replicas of the genes for ribosomal RNA.Science. 1968 Apr 19;160(3825):272-80 PMID: 4867987
-
Properties and composition of the isolated ribosomal DNA satellite of Xenopus laevis.Nature. 1968 Aug 3;219(5153):454-63 PMID: 5668424
-
Localization of amplified ribosomal DNA in the oocyte of Xenopus laevis.Biochim Biophys Acta. 1968 Aug 23;166(1):274-6 PMID: 5698061
-
Differential synthesis of the genes for ribosomal RNA during amphibian oögenesis.Proc Natl Acad Sci U S A. 1968 Jun;60(2):553-60 PMID: 5248812
-
The replication of purified DNA introduced into living egg cytoplasm.Biochim Biophys Acta. 1969 Feb 18;174(2):614-28 PMID: 5813317
-
Patterns of macromolecule synthesis during development of Xenopus laevis. II. Identification of the 40 S precursor to ribosomal RNA.Dev Biol. 1969 Mar;19(3):244-60 PMID: 5788897
-
The genes for ribosomal RNA during oögenesis.Genetics. 1969;61(1):Suppl:121-32 PMID: 5345375
-
Properties of the ribosomal RNA precursor in Xenopus laevis; comparison to the precursor in mammals and in plants.J Mol Biol. 1969 Oct 28;45(2):353-66 PMID: 5367033
-
RNA-dependent DNA polymerase in virions of RNA tumour viruses.Nature. 1970 Jun 27;226(5252):1209-11 PMID: 4316300
-
RNA-dependent DNA polymerase in virions of Rous sarcoma virus.Nature. 1970 Jun 27;226(5252):1211-3 PMID: 4316301
-
Composition and structure of chromosomal and amplified ribosomal DNA's of Xenopus laevis.J Mol Biol. 1970 Jul 28;51(2):341-60 PMID: 5485907
-
Ribonucleic acids and ribonucleoproteins from small oöcytes of Xenopus laevis.Biochim Biophys Acta. 1970 Nov 12;224(1):99-113 PMID: 5490269
-
[Biochemical studies on oogenesis. I. RNA synthesis and accumulation during oogenesis of the South African toad Xenopus laevis].Dev Biol. 1971 Feb;24(2):143-65 PMID: 5553364
-
Inhibitors of the RNA and DNA dependent polymerase activities of RNA tumour viruses.Nat New Biol. 1971 Jan 27;229(4):111-4 PMID: 4326810
-
Gene linkage by RNA-DNA hybridization. II. Arrangement of the redundant gene sequences for 28 s and 18 s ribosomal RNA.J Mol Biol. 1968 Jun 28;34(3):681-97 PMID: 5760468
-
The ribosomal RNA cistrons.Prog Nucleic Acid Res Mol Biol. 1971;11:351-89 PMID: 5004308
-
VARIATIONS IN THE SYNTHESIS OF STABLE RNA'S DURING OOGENESIS AND DEVELOPMENT OF XENOPUS LAEVIS.J Mol Biol. 1964 May;8:688-95 PMID: 14187394
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
