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PMID: 5288388 Published · ppublish English Journal Article

RNA-dependent RNA polymerase activity in influenza virions.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 6 ·1971-06-00 ·Pages 1369-71

Penhoet E, Miller H, Doyle M, Blatti S

Abstract

An RNA-dependent RNA polymerase activity has been detected in purified preparations of influenza virus. In contrast to the replicase activity induced in influenza-infected cells, the virion-associated enzyme has an absolute requirement for Mn(++). Most of the RNA synthesized in vitro is complementary to virion RNA.

MeSH Terms
Ammonium Sulfate/pharmacology Centrifugation, Density Gradient Magnesium/pharmacology Manganese/pharmacology Orthomyxoviridae/enzymology RNA Nucleotidyltransferases/analysis,isolation & purification,pharmacology RNA, Viral Tritium Uracil Nucleotides/metabolism Virus Cultivation
Chemicals
RNA, Viral Uracil Nucleotides Tritium Manganese RNA Nucleotidyltransferases Magnesium Ammonium Sulfate
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Penhoet E
Miller H
Doyle M
Blatti S
References (13)
13 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.68.6.1369
Published
1971-06-00
Pages
1369-71
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC389191
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.68.6.1369 PMC Full Text View journal details
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