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PMID: 5312691 Published · ppublish English Journal Article

Time-dependent effects of inosine on competence development in Haemophilus influenzae.

Journal of bacteriology ·Vol. 104 ·No. 2 ·1970-11-00 ·Pages 775-9

Miller DH, Huang PC

Abstract

The effect of inosine on the development of competence is dependent upon the time at which it is added to the competence medium. Competence is inhibited if inosine is added within 15 min after the development begins, but is stimulated if the addition is made at later times. Protein synthesis is stimulated by the addition of inosine, but the effect is quantitatively similar regardless of the time at which inosine is added.

MeSH Terms
Bacterial Proteins/biosynthesis Carbon Isotopes Culture Media DNA, Bacterial Haemophilus influenzae/drug effects,growth & development,metabolism Nucleosides/metabolism,pharmacology Phenylalanine/metabolism Spectrophotometry Time Factors Transformation, Genetic Tritium
Chemicals
Bacterial Proteins Carbon Isotopes Culture Media DNA, Bacterial Nucleosides Tritium Phenylalanine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Miller D H
Huang P C
References (7)
7 references, click to expand
  1. Development of competence of Haemophilus influenzae.
    J Bacteriol. 1965 Oct;90(4):911-20 PMID: 5294817
  2. Inosine and lactate: factors critical during growth for development of competence in Haemophilus influenzae.
    Biochem Biophys Res Commun. 1966 Mar 8;22(5):591-6 PMID: 5296448
  3. Defined medium for growth of Haemophilus influenzae.
    J Bacteriol. 1970 Feb;101(2):513-6 PMID: 5308770
  4. Defined nongrowth media for stage II development of competence in Haemophilus influenzae.
    J Bacteriol. 1970 Feb;101(2):517-24 PMID: 5308771
  5. Thymine and thymidine uptake by Haemophilus influenzae and the labeling of deoxyribonucleic acid.
    J Bacteriol. 1970 Feb;101(2):525-30 PMID: 5308772
  6. Studies on transformations of Hemophilus influenzae. I. Competence.
    J Gen Physiol. 1961 Jul;44:1201-27 PMID: 13707010
  7. The genetics of transformation.
    Adv Genet. 1961;10:61-163 PMID: 14490656
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
Published
1970-11-00
Pages
775-9
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC285057
Subset
IM
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