Inhibition or enhancement of immunological injury of virus-infected cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 12 ·1971-12-00 ·Pages 3073-7

Brier AM, Wohlenberg C, Rosenthal J, Mage M, Notkins AL

Abstract

Within hours after infection of cells with herpes simplex, vaccinia, influenza, or Newcastle disease virus, new antigens appeared on the surface of infected cells. The interaction of specific antiviral antibody and complement with these antigens resulted in cell destruction, which was quantitated by the release of (51)Cr. A number of factors can influence the degree of cell destruction, including the density of viral antigens on the surface of infected cells, the nature of the antiviral antibody, and the presence of anti-immunoglobulins. The immunological destruction of virus-infected cells may on the one hand serve as a defense mechanism against certain viral infections, while on the other hand it may contribute to the pathology of the host.

MeSH Terms

Animals Antibodies, Anti-Idiotypic Antibody Specificity Antigen-Antibody Reactions Antigens, Viral Cell Line Cell Survival Cells/immunology Cells, Cultured Chromium Isotopes Complement System Proteins Goats HeLa Cells Herpes Simplex/immunology Humans Immune Sera Influenza, Human/immunology Kidney Lung Newcastle Disease/immunology Poultry Rabbits Species Specificity Vaccinia/immunology

Chemicals

Antibodies, Anti-Idiotypic Antigens, Viral Chromium Isotopes Immune Sera Complement System Proteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Brier A M

Wohlenberg C

Rosenthal J

Mage M

Notkins A L

References (12)

12 references, click to expand

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Expression of H-2 and Moloney leukemia virus-determined cell-surface antigens in synchronized cultures of a mouse cell line.
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.12.3073

Published

1971-12-00

Pages

3073-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC389593

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.12.3073 PMC Full Text View journal details

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Inhibition or enhancement of immunological injury of virus-infected cells.

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