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PMID: 5326090 Published · ppublish English Journal Article

Effects of mutations to streptomycin resistance on the rate of translation of mutant genetic information.

Journal of bacteriology ·Vol. 91 ·No. 3 ·1966-03-00 ·Pages 1021-8

Gartner TK, Orias E

Abstract

Gartner, T. K. (University of California, Santa Barbara), and E. Orias. Effects of mutations to streptomycin resistance on the rate of translation of mutant genetic information. J. Bacteriol. 91:1021-1028. 1966.-The effects of mutations to streptomycin resistance of independent origin upon the translation of suppressible mutant information were studied in an isogenic series of strains of Escherichia coli. The group of suppressible mutants included 1 mutation in the z gene of the lac operon of E. coli (O(0) (2) allele), 12 mutations distributed among the two rII cistrons of T4, and 13 mutations distributed among at least five cistrons of phage T7. It was concluded that the mutations to streptomycin resistance cause a significant decrease in the rate of translation of the suppressible codons, and that this effect is limited to a few types of codons.

MeSH Terms
Chromosome Mapping Drug Resistance, Microbial Enzyme Repression Escherichia coli Galactosidases Genetic Code In Vitro Techniques Mutation Streptomycin/pharmacology
Chemicals
Galactosidases Streptomycin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gartner T K
Orias E
References (25)
25 references, click to expand
  1. THE RELATION OF CATABOLITE REPRESSION TO THE INDUCTION SYSTEM FOR BETA-GALACTOSIDASE IN ESCHERICHIA COLI.
    J Mol Biol. 1964 Mar;8:417-26 PMID: 14168695
  2. SUPPRESSION OF A CLASS OF RII MUTANTS OF T4 BY A SUPPRESSOR OF A LAC -"OPERATOR NEGATIVE" MUTATION.
    Proc Natl Acad Sci U S A. 1964 Sep;52:859-64 PMID: 14212564
  3. Transduction of lactose-utilizing ability among strains of E. coli and S. dysenteriae and the properties of the transducing phage particles.
    Virology. 1960 Nov;12:348-90 PMID: 13764402
  4. Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor.
    Science. 1965 Jul 23;149(3682):417-22 PMID: 17809404
  5. Biosynthesis of B-D-galactosidase controlled by phage-carried genes. I. Induced beta-D-galactosidase biosynthesis after transduction of gene z-plus by phage.
    Proc Natl Acad Sci U S A. 1961 Dec 15;47:1956-67 PMID: 14491633
  6. PLEIOTROPIC EFFECTS OF SUPPRESSORS OF A LAC-"OPERATOR NEGATIVE" MUTATION IN ESCHERICHIA COLI.
    Proc Natl Acad Sci U S A. 1965 Jan;53:62-8 PMID: 14283206
  7. Genetic code: the 'nonsense' triplets for chain termination and their suppression.
    Nature. 1965 Jun 5;206(988):994-8 PMID: 5320272
  8. ON THE TOPOGRAPHY OF THE GENETIC FINE STRUCTURE.
    Proc Natl Acad Sci U S A. 1961 Mar;47(3):403-15 PMID: 16590840
  9. An active cistron fragment.
    J Mol Biol. 1962 Apr;4:288-92 PMID: 13877974
  10. The inheritance of streptomycin resistance and dependence in crosses of Escherichia coli.
    Genetics. 1950 Nov;35(6):603-11 PMID: 14793705
  11. A change from nonsense to sense in the genetic code.
    Proc Natl Acad Sci U S A. 1962 Jul 15;48:1114-21 PMID: 13867417
  12. ON THE TOPOLOGY OF THE GENETIC FINE STRUCTURE.
    Proc Natl Acad Sci U S A. 1959 Nov;45(11):1607-20 PMID: 16590553
  13. AMBIVALENT rII MUTANTS OF PHAGE T4.
    Proc Natl Acad Sci U S A. 1961 Jul;47(7):1025-38 PMID: 16590849
  14. Genetic analysis of a "double male" strain of Escherichia coli K-12.
    Genetics. 1963 Jan;48:105-20 PMID: 14021492
  15. Suppression of mutations in the alkaline phosphatase structural cistron of E. coli.
    Proc Natl Acad Sci U S A. 1962 Jul 15;48:1121-7 PMID: 13896933
  16. Streptomycin Resistance in Escherichia Coli Analyzed by Transduction.
    Genetics. 1960 Jan;45(1):49-62 PMID: 17247907
  17. RESTORATION OF OPERON ACTIVITY BY SUPPRESSORS.
    Biochim Biophys Acta. 1963 Sep 17;76:162-4 PMID: 14068553
  18. Streptomycin resistance; a genetically recessive mutation.
    J Bacteriol. 1951 May;61(5):549-50 PMID: 14832197
  19. An inducible mechanism for accumulation of melibiose in Escherichia coli.
    J Bacteriol. 1957 Mar;73(3):376-85 PMID: 13416199
  20. PHENOTYPIC REPAIR BY STREPTOMYCIN OF DEFECTIVE GENOTYPES IN E. COLI.
    Proc Natl Acad Sci U S A. 1964 Mar;51:487-93 PMID: 14171463
  21. INTERACTION OF STREPTOMYCIN AND A SUPPRESSOR FOR GALACTOSE FERMENTATION IN E. COLI K-12.
    Proc Natl Acad Sci U S A. 1964 Apr;51:678-82 PMID: 14166774
  22. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  23. Ribosomal protein differences in a strain of E. coli carrying a suppressor of an ochre mutation.
    Biochem Biophys Res Commun. 1965 Oct 8;21(1):66-71 PMID: 5325233
  24. STREPTOMYCIN ACTION AND THE RIBOSOME.
    Proc Natl Acad Sci U S A. 1964 Apr;51:703-9 PMID: 14166778
  25. STUDIES ON THE RIBOSOMES OF STREPTOMYCIN-SENSITIVE AND RESISTANT STRAINS OF ESCHERICHIA COLI.
    Proc Natl Acad Sci U S A. 1964 Apr;51:659-64 PMID: 14166773
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.91.3.1021-1028.1966
Published
1966-03-00
Pages
1021-8
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC315993
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.91.3.1021-1028.1966 PMC Full Text View journal details
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