Leukocyte bactericidal activity in chronic granulomatous disease: correlation of bacterial hydrogen peroxide production and susceptibility to intracellular killing.

Journal of bacteriology ·Vol. 100 ·No. 1 ·1969-10-00 ·Pages 531-2

Mandell GL, Hook EW

Abstract

Susceptibility of bacteria to intracellular killing by polymorphonuclear leukocytes from a patient with chronic granulomatous disease could be correlated with bacterial hydrogen peroxide production.

MeSH Terms

Bacteria/enzymology,metabolism Blood Bactericidal Activity Catalase/metabolism Chronic Disease Granuloma/blood Humans Hydrogen Peroxide/biosynthesis Infant, Newborn Infant, Newborn, Diseases/blood Infections/blood Leukocytes Lymphadenitis/blood

Chemicals

Hydrogen Peroxide Catalase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Mandell G L

Hook E W

References (7)

7 references, click to expand

Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function.
J Clin Invest. 1967 Sep;46(9):1422-32 PMID: 6036538
Iodination of bacteria: a bactericidal mechanism.
J Exp Med. 1967 Dec 1;126(6):1063-78 PMID: 4964565
Studies of polymorphonuclear leukocytes from patients with chronic granulomatous disease of childhood: bactericidal capacity for streptococci.
Pediatrics. 1968 Mar;41(3):591-9 PMID: 4966707
Influence of catalase activity on resistance of coagulase-positive staphylococci to hydrogen peroxide.
Appl Microbiol. 1968 Feb;16(2):267-70 PMID: 5645413
In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood.
J Clin Invest. 1967 Apr;46(4):668-79 PMID: 6021213
Iodination defect in the leukocytes of a patient with chronic granulomatous disease of childhood.
N Engl J Med. 1969 Feb 27;280(9):460-6 PMID: 4974160
Peroxide and peroxidogenic bacteria in human saliva.
J Bacteriol. 1957 Jun;73(6):727-35 PMID: 13449038

Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/jb.100.1.531-532.1969

Published

1969-10-00

Pages

531-2

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC315425

Subset

External Links

PubMed source DOI: 10.1128/jb.100.1.531-532.1969 PMC Full Text View journal details

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Leukocyte bactericidal activity in chronic granulomatous disease: correlation of bacterial hydrogen peroxide production and susceptibility to intracellular killing.

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